SML2830

trans-Ned-19

≥98% (HPLC)

• Sinônimo(s): (1R,3S)-)-1-[3-[[4-(2-Fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid, Ned-19, trans (1R,3S)-NED-19
• Fórmula empírica (Notação de Hill): C₃₀H₃₁FN₄O₃
• Número CAS: 1354235-96-3
• Peso molecular: 514.59
• Número MDL: MFCD31562774
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: −20°C
• InChI: 1S/C30H31FN4O3/c1-38-27-11-10-19(16-20(27)18-34-12-14-35(15-13-34)26-9-5-3-7-23(26)31)28-29-22(17-25(33-28)30(36)37)21-6-2-4-8-24(21)32-29/h2-11,16,25,28,32-33H,12-15,17-18H2,1H3,(H,36,37)/t25-,28+/m0/s1
• chave InChI: FUHCEERDBRGPQZ-LBNVMWSVSA-N

Descrição

Ações bioquímicas/fisiológicas

NAADP (nicotinic acid adenine dinucleotide phosphate) has recently been recognized as a crucial Ca²⁺-releasing second messenger in several mammalian tissues including pancreatic, brain and cardiac. Ned-19 is a potent inhibitor of NAADP action. It is a selective blocker of cellular NAADP-induced Ca²⁺-release and can fluorescently label NAADP receptors. Ned-19 blocks NAADP signaling at nanomolar concentrations. In intact cells, Ned-19 blocked NAADP signaling and fluorescently labeled NAADP receptors.The trans-Ned-19 is more potent than the cis form in regard to both inhibition of Ca²⁺ release (IC₅₀ of 6 nM versus 800 nM) and [32P]NAADP binding (IC₅₀ of 0.4 nM versus 15 μM).

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3