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Documentos

S7942

Sigma-Aldrich

Sirtinol

≥95% (HPLC)

Sinônimo(s):

2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide

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About This Item

Fórmula empírica (Notação de Hill):
C26H22N2O2
Número CAS:
410536-97-9
Peso molecular:
394.47
Número MDL:
MFCD00810186
Código UNSPSC:
12352203
ID de substância PubChem:
24899771
NACRES:
NA.77

Nível de qualidade

200

Ensaio

≥95% (HPLC)

forma

solid

solubilidade

DMSO: soluble

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC(NC(=O)c1ccccc1\N=C\c2c(O)ccc3ccccc23)c4ccccc4

InChI

1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)/b27-17+

chave InChI

UXJFDYIHRJGPFS-WPWMEQJKSA-N

Informações sobre genes

human ... SIRT1(23411) , SIRT2(22933)

Aplicação

HUVEC were treated with sirtinol to study the effect on induction of transcription factor Krüppel-like factor 2.4 Sirtinol was used to treat human embryonic kidney cells to study the effect on the expression on Werner syndrome protein.5

Ações bioquímicas/fisiológicas

Sirtinol inhibits yeast Sir2p transcriptional silencing activity in vivo, yeast Sir2p and human SIRT2 deacetylase activity in vitro. It inhibits the physiological regulators of platelet aggregation such as thrombin and collagen, attenuates intracellular Ca2+ release and formation thromboxane B2. It may increase levels of cAMP by inhibition of cAMP phosphodiesterase and inhibit the aggregation of platelets.2 Sirtinol reduces inflammatory responses of human dermal microvascular endothelial cells to TNF-α and IL-1β.3
Sirtinol inhibits yeast Sir2p transcriptional silencing activity in vivo, yeast Sir2p, and human SIRT2 deacetylase activity in vitro.

Características e benefícios

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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AK-7 ≥98% (HPLC)

Sigma-Aldrich

SML0152

AK-7

Sivelestat sodium salt hydrate ≥98% (HPLC), solid

Sigma-Aldrich

S7198

Sivelestat sodium salt hydrate

SirReal2 ≥98% (HPLC)

Sigma-Aldrich

SML1514

SirReal2

SAHA ≥98% (HPLC)

Sigma-Aldrich

SML0061

SAHA

SIRT1 Inhibitor III The SIRT1 Inhibitor III, also referenced under CAS 49843-98-3, controls the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Cell Structure applications.

Millipore

566322-M

SIRT1 Inhibitor III

Apicidin ≥98% (HPLC), from microbial

Sigma-Aldrich

A8851

Apicidin

Angela Orecchia et al.
PloS one, 6(9), e24307-e24307 (2011-09-21)
Histone deacetylases (HDAC) are key enzymes in the epigenetic control of gene expression. Recently, inhibitors of class I and class II HDAC have been successfully employed for the treatment of different inflammatory diseases such as rheumatoid arthritis, colitis, airway inflammation
Jorge Gracia-Sancho et al.
Cardiovascular research, 85(3), 514-519 (2009-10-10)
Resveratrol activates Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase which modulates metabolic homeostasis and improves several pathophysiological features present in diseases of ageing. In particular, it has been shown that SIRT1 activation improves endothelial dysfunction and suppresses vascular inflammation
H Mutoh et al.
The American journal of physiology, 261(1 Pt 1), G65-G70 (1991-07-01)
We examined the role of reduced glutathione as a defense mechanism against acid-induced gastric mucosal cell damage in vitro. Cellular stores of reduced glutathione were depleted by reaction with diethyl maleate (DEM) or 1-chloro-2,4-dinitrobenzene (CDNB) and increased by reaction with
Jun Feng et al.
European journal of pharmacology, 791, 632-639 (2016-10-30)
Tanshinone IIA (Tan) exerts potential protective effects against cardiovascular diseases. Oxidative stress and inflammation are involved in cardiac hypertrophy. Activation of silent information regulator 1 (SIRT1) signaling has been suggested to attenuate cardiac hypertrophy. This study aims to evaluate the
Mina Eriksson et al.
International journal of radiation oncology, biology, physics, 100(1), 174-187 (2017-11-07)
We previously reported that sphere-forming non-small cell lung cancer (NSCLC) tumor-initiating cells (TICs) have an altered activation of DNA damage response- and repair proteins and are refractory to DNA-damaging treatments. We analyzed whether chromatin organization plays a role in the
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