P7136
Pyrazinecarboxamide
Sinônimo(s):
Pyrazinamide, Pyrazinoic acid amide
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About This Item
Fórmula empírica (Notação de Hill):
C5H5N3O
Número CAS:
Peso molecular:
123.11
Beilstein:
112306
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.85
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Formulário
powder
Nível de qualidade
pf
189-191 °C (lit.)
espectro de atividade do antibiótico
mycobacteria
Modo de ação
cell membrane | interferes
cadeia de caracteres SMILES
NC(=O)c1cnccn1
InChI
1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
chave InChI
IPEHBUMCGVEMRF-UHFFFAOYSA-N
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Aplicação
Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention and mechanisms of resistance .
Ações bioquímicas/fisiológicas
The active moiety of pyrazinamide is pyrazinoic acid (POA). POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis. Iron enhances the antituberculous activity of pyrazinamide . Pyrazinamide and its analogs have been shown to inhibit the activity of purified FAS I.
Outras notas
Keep container tightly closed in a dry and well-ventilated place.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Thirty-four pyrazinamide-resistant and 37 pyrazinamide-susceptible Mycobacterium tuberculosis complex strains were analyzed for pncA gene mutations. None of the sensitive strains had any mutations, apart from silent mutations, whereas all but one resistant strain showed pncA mutations. By using sequencing as
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