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I3377

Supelco

Isoniazid

analytical standard, ≥99% (TLC)

Sinônimo(s):

4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide

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About This Item

Fórmula empírica (Notação de Hill):
C6H7N3O
Número CAS:
54-85-3
Peso molecular:
137.14
Beilstein:
119374
Número CE:
200-214-6
Número MDL:
MFCD00006426
Código UNSPSC:
41116107
ID de substância PubChem:
329815370
NACRES:
NA.24

grau

analytical standard

Nível de qualidade

100

Ensaio

≥99% (TLC)

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

pf

171-173 °C (lit.)

fluorescência

λex 360 nm; λem 450 nm (thiol adduct)

espectro de atividade do antibiótico

mycobacteria

aplicação(ões)

forensics and toxicology
pharmaceutical (small molecule)

formato

neat

cadeia de caracteres SMILES

NNC(=O)c1ccncc1

InChI

1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)

chave InChI

QRXWMOHMRWLFEY-UHFFFAOYSA-N

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Categorias relacionadas

Descrição geral

Chemical structure: pyridine
Isoniazid is a type of drug possessing antimycobacterial activity.It is used in the treatment of tuberculosis.

Aplicação

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Ações bioquímicas/fisiológicas

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

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Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H315

Classificações de perigo

Acute Tox. 4 Oral - Skin Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
MKCQ3516
MKCN7197
MKCL5688
MKCJ5583
MKCG7373

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Pyrazinecarboxamide

Sigma-Aldrich

P7136

Pyrazinecarboxamide

Pyrazinamide British Pharmacopoeia (BP) Reference Standard

BP906

Pyrazinamide

Ethambutol hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1930

Ethambutol hydrochloride

Dihydrostreptomycin sesquisulfate

Sigma-Aldrich

D7253

Dihydrostreptomycin sesquisulfate

2-Thiophenecarboxylic acid hydrazide ≥98%

Sigma-Aldrich

T1388

2-Thiophenecarboxylic acid hydrazide

Isoniazid could be used for antibiotic-loaded bone cement for musculoskeletal tuberculosis: an in vitro study
Han DC, et al.
Clinical Orthopaedics and Related Research, 471(7), 2400-2406 (2013)
Ram Shankar Upadhayaya et al.
European journal of medicinal chemistry, 45(5), 1854-1867 (2010-02-09)
We have designed and synthesized both the quinoline and naphthalene based molecules influenced by the unique structural make-up of mefloquine and TMC207, respectively. These compounds were evaluated for their anti-mycobacterial activity against drug sensitive Mycobacterium tuberculosis H37Rv in vitro at
Samantha Ellis et al.
Molecular pharmacology, 85(2), 269-278 (2013-11-19)
The rise in drug-resistant strains of Mycobacterium tuberculosis is a major threat to human health and highlights the need for new therapeutic strategies. In this study, we have assessed whether high-affinity iron chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class
Standardized treatment of active tuberculosis in patients with previous treatment and/or with mono-resistance to isoniazid: a systematic review and meta-analysis.
Dick Menzies et al.
PLoS medicine, 6(9), e1000150-e1000150 (2010-01-28)
Anandi Martin et al.
The Journal of antimicrobial chemotherapy, 62(1), 56-64 (2008-04-15)
The reference standard methods for drug susceptibility testing (DST) of M. tuberculosis are very slow to give results, and due to the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis, there is an urgent demand for new, rapid and
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