PZ0014

Linezolid

≥98% (HPLC), powder, bacterial mRNA translation inhibitor

• Sinônimo(s): N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, PNU-100766, U-100766
• Fórmula empírica (Notação de Hill): C₁₆H₂₀FN₃O₄
• Número CAS: 165800-03-3
• Peso molecular: 337.35
• Número MDL: MFCD00937825
• Código UNSPSC: 12352200
• ID de substância PubChem: 329823683
• NACRES: NA.77

Propriedades

• Nome do produto: Linezolid, ≥98% (HPLC)
• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to off-white
• solubilidade: DMSO: >20 mg/mL
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: CC(=O)NC[C@H]1CN(C(=O)O1)c2ccc(N3CCOCC3)c(F)c2
• InChI: 1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
• chave InChI: TYZROVQLWOKYKF-ZDUSSCGKSA-N

Descrição

Descrição geral

Linezolid exhibits its activity against several Gram-positive bacteria including penicillin-resistant, methicillin-resistant, and vancomycin- resistant. Linezolid can decrease the rate of translation reaction by inhibiting the formation of initiation complex thereby reducing the length of the newly formed peptidechain. Additionally, it may also play a role in reducing the virulence leading to reduced toxins produced by Gram-positive bacteria.

Aplicação

Linezolid has been used in checkerboard-type drug combination MIC (minimum inhibitory concentrations) assay to determine whether ivacaftor shows positive interaction with linezolid. It has been used for the determination of minimum biofilm inhibitory concentration and for the treatment of Mycobacterium abscessus-infected Drosophila melanogaster w1118 flies.Linezolid has been used as an antibiotic to study its effects on the development of malaria-associated acute respiratory distress syndrome (MAARDS) in rat lungs. It has been used as an antibiotic to study its effects in combination with baicalein on methicillin-resistant Staphylococcus aureus strains. It has been used as an antibiotic to study its effects on planktonic growth and formation of biofilms by Enterococcus faecalis.

Ações bioquímicas/fisiológicas

Linezolid is an oxazolidinine antimicrobial. It inhibits bacterial mRNA translation and a weak, reversible, nonselective inhibitor of monoamine oxidase.

Linezolid is an oxazolidinone antimicrobial. It binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex, thus inhibiting bacterial mRNA translation. Linezolid is also a weak, reversible, nonselective inhibitor of monoamine oxidase.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H372
• Declarações de precaução: P260 - P264 - P270 - P314 - P501
• Classificações de perigo: STOT RE 1 Oral
• Órgãos-alvo: Bone
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable