SML1581

Moxifloxacin hydrochloride

≥98% (HPLC)

• Sinônimo(s): 12-8039, Avalox, BAY12-8039, 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
• Fórmula empírica (Notação de Hill): C₂₁H₂₄FN₃O₄· HCl
• Número CAS: 186826-86-8
• Peso molecular: 437.89
• Beilstein: 8377447
• Número MDL: MFCD00949117
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825971
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• atividade óptica: [α]/D -119 to -139°, c = 0.5 in water
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: H₂O: 5 mg/mL, clear (warmed)
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: Cl.COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc4C(=O)C(=CN(C5CC5)c14)C(O)=O
• InChI: 1S/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24;/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28);1H/t11-,16+;/m0./s1
• chave InChI: IDIIJJHBXUESQI-DFIJPDEKSA-N

Descrição

Descrição geral

Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial. Moxifloxacin is a 8-methoxy quinolone and differs from other quinolones.

Aplicação

Moxifloxacin hydrochloride has been used to study its antibacterial action against bacteria that have grown to high density.

Ações bioquímicas/fisiológicas

Moxifloxacin has proved to be effective in treating sinusitis, community-acquired respiratory tract infection, pneumonia and acute exacerbations of chronic bronchitis. It has improved anti-gram positive activity compared to other fluoroquinolone such as ciprofloxacin and ofloxacin. Moxifloxacin is useful in treating skin infections that is of bacterial origin. It is known to have proper penetration into peripheral tissues and inflammatory fluids. Fluoroquinolones stabilize DNA strand breaks created by DNA gyrase and topoisomerase IV by binding to the enzyme-DNA complex. Compared to mammalian DNA gyrase, moxifloxacin has 100 times higher affinity for bacterial DNA gyrase. Moxifloxacin is an antibiotic and works against both Gram-positive and Gram-negative bacteria. Moxifloxacin is being investigated for the treatment of multidrug-resistant tuberculosis.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302,H319,H412
• Declarações de precaução: P264 - P270 - P273 - P280 - P301 + P312 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable