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Documentos Principais

PHR1576

Supelco

Pyrazinamide

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

Pyrazinecarboxamide, Pyrazinamide, Pyrazinoic acid amide

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About This Item

Fórmula empírica (Notação de Hill):
C5H5N3O
Número CAS:
Peso molecular:
123.11
Beilstein:
112306
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to BP 906
traceable to Ph. Eur. P4050000
traceable to USP 1585006

família API

pyrazinamide

Certificado de análise (CofA)

current certificate can be downloaded

embalagem

pkg of 500 mg

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

pf

189-191 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-30°C

cadeia de caracteres SMILES

NC(=O)c1cnccn1

InChI

1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)

chave InChI

IPEHBUMCGVEMRF-UHFFFAOYSA-N

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Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pyrazinamide is an analog of nicotinamide. It is an antituberculosis drug and plays a vital role in reducing the duration of chemotherapy of tuberculosis.

Aplicação

Pyrazinamide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography and multivariate spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAA4492 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produtos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Liquid chromatographic determination of isoniazid, pyrazinamide and rifampicin from pharmaceutical preparations and blood.
Khuhawar MY and Rind FMA
Journal of Chromatography. B, Biomedical Sciences and Applications, 766(2), 357-363 (2002)
Simultaneous determination of rifampicin, isoniazid and pyrazinamide in tablet preparations by multivariate spectrophotometric calibration.
Goicoechea HC and Olivieri AC
Journal of Pharmaceutical and Biomedical Analysis, 20(4), 681-686 (1999)
Validation of a RP-LC method for the simultaneous determination of isoniazid, pyrazinamide and rifampicin in a pharmaceutical formulation.
Calleri E, et al.
Journal of Pharmaceutical and Biomedical Analysis, 29(6), 1089-1096 (2002)

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