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P5084

Sigma-Aldrich

PTIO

Sinônimo(s):

2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide

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About This Item

Fórmula empírica (Notação de Hill):
C13H17N2O2
Número CAS:
18390-00-6
Peso molecular:
233.29
Número MDL:
MFCD00059929
Código UNSPSC:
12352200
ID de substância PubChem:
329820215
NACRES:
NA.32

forma

powder

Nível de qualidade

200

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC1(C)N([O])C(c2ccccc2)=[N+]([O-])C1(C)C

InChI

1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3

chave InChI

DYUUGILMVYJEHY-UHFFFAOYSA-N

Aplicação

2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIO) has been used as a nitric oxide (NO) scavenger.

Ações bioquímicas/fisiológicas

2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIOs) derivatives react with nitric oxide (NO) to yield the corresponding imino nitroxides (PTIs) and nitrogen dioxide (NO2).
A stable radical scavenger for nitric oxide; affects NO without affecting NO synthase; has significant inhibitory activity against NO biological actions.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Supelco

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Sigma-Aldrich

M7033

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Hypotaurine ≥98% (TLC)

Sigma-Aldrich

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Sigma-Aldrich

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Jiu-Gang Xue et al.
Journal of neurophysiology, 105(6), 2897-2906 (2011-04-08)
N-methyl-D-aspartate (NMDA) receptors (NMDARs) are implicated in synaptic plasticity and modulation of glutamatergic excitatory transmission. Effect of NMDAR activation on inhibitory GABAergic transmission remains largely unknown. Here, we report that a brief application of NMDA could induce two distinct actions
Reactions of PTIO and carboxy-PTIO with *NO, *NO2, and O2-*.
Goldstein S
The Journal of Biological Chemistry, 278 (51), 50949-50955 (2003)
Christal G Coleman et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(36), 12103-12112 (2010-09-10)
Chronic intermittent hypoxia (CIH) is a concomitant of sleep apnea that produces a slowly developing chemosensory-dependent blood pressure elevation ascribed in part to NMDA receptor-dependent plasticity and reduced nitric oxide (NO) signaling in the carotid body. The hypothalamic paraventricular nucleus
Victor Parro et al.
Frontiers in microbiology, 10, 929-929 (2019-05-28)
Potential benthic habitats of early Mars lakes, probably oligotrophic, could range from hydrothermal to cold sediments. Dynamic processes in the water column (such as turbidity or UV penetration) as well as in the benthic bed (temperature gradients, turbation, or sedimentation
Victoria P A Johnstone et al.
Learning & memory (Cold Spring Harbor, N.Y.), 18(10), 625-633 (2011-09-22)
Long-term potentiation (LTP) is an important process underlying learning and memory in the brain. At CA3-CA1 synapses in the hippocampus, three discrete forms of LTP (LTP1, 2, and 3) can be differentiated on the basis of maintenance and induction mechanisms.
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