M7033

N^G-Methyl-L-arginine acetate salt

≥98% (TLC), powder, nitric oxide synthase inhibitor

• Sinônimo(s): N_ω-Methyl-L-arginine acetate salt, L-NMMA, N⁵-(Methylamidino)-L-ornithine acetate salt, N^G-Monomethyl-L-arginine acetate salt
• Fórmula empírica (Notação de Hill): C₇H₁₆N₄O₂ · C₂H₄O₂
• Número CAS: 53308-83-1
• Peso molecular: 248.28
• Beilstein: 6674255
• Número MDL: MFCD00069311
• Código UNSPSC: 12352209
• ID de substância PubChem: 24278043
• NACRES: NA.77

Propriedades

• product name: N^G-Methyl-L-arginine acetate salt, ≥98% (TLC)
• Nível de qualidade: 200
• Ensaio: ≥98% (TLC)
• forma: powder
• solubilidade: water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• cadeia de caracteres SMILES: CC(O)=O.CNC(=N)NCCC[C@H](N)C(O)=O
• InChI: 1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
• chave InChI: IKPNWIGTWUZCKM-JEDNCBNOSA-N
• Informações sobre genes: human ... NOS1(4842) , NOS2(4843) , NOS3(4846) ; mouse ... Nos2(18126) ; rat ... Nos1(24598) , Nos2(24599)

Descrição

Aplicação

N^G-Methyl-L-arginine acetate salt has been used:

• as an inhibitor of nitric oxide synthase (NOS) in wound healing studies in injured mice
• as an inhibitor of nitric oxide synthase (NOS) to study nitric oxide (NO) immunosuppressive effect of murine stem cells
• as an inhibitor to monitor NO levels in hemocytes respiratory burst assay

Ações bioquímicas/fisiológicas

N^G-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.

Características e benefícios

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)