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D5431

Sigma-Aldrich

Diethylamine NONOate diethylammonium salt

≥98%

Sinônimo(s):

DEA NONOate, DEA/NO diethylammonium salt

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About This Item

Fórmula linear:
(CH3CH2)2N–N(N=O)O- (CH3CH2)2NH2+
Número CAS:
372965-00-9
Peso molecular:
206.29
Número MDL:
MFCD00216152
Código UNSPSC:
12352116
ID de substância PubChem:
329798805
NACRES:
NA.22

descrição

t1/2 16 min phosphate buffer, 22 °C NO release

Ensaio

≥98%

forma

solid

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

cadeia de caracteres SMILES

CCNCC.CCN(CC)N(O)N=O

InChI

1S/C4H11N3O2.C4H11N/c1-3-6(4-2)7(9)5-8;1-3-5-4-2/h9H,3-4H2,1-2H3;5H,3-4H2,1-2H3

chave InChI

LBJLVZKEUWCGIA-UHFFFAOYSA-N

Aplicação

DEA/NO diethylammonium salt can be used as:        
  • A nitric oxide (NO) donor.
  • A reagent for reductive nitrosylation of Wilkinson′s catalyst.

Used as:
  • Reagent for reductive nitrosylation of Wilkinson′s catalyst
  • Nitric oxide (NO) donor

Ações bioquímicas/fisiológicas

NO donor

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Joseph C Galley et al.
Molecular pharmacology, 95(6), 629-637 (2019-04-17)
Nitric oxide (NO) stimulates soluble guanylyl cyclase (sGC) activity, leading to elevated intracellular cyclic guanosine 3',5'-monophosphate (cGMP) and subsequent vascular smooth muscle relaxation. It is known that downregulation of sGC expression attenuates vascular dilation and contributes to the pathogenesis of
Xin Zhang et al.
The Journal of biological chemistry, 277(50), 48472-48478 (2002-10-09)
4,5-Diaminofluorescein (DAF-2) is widely used for detection and imaging of NO based on its sensitivity, noncytotoxicity, and specificity. In the presence of oxygen, NO and NO-related reactive nitrogen species nitrosate 4,5-diaminofluorescein to yield the highly fluorescent DAF-2 triazole (DAF-2T). However
Xi Ye et al.
The Journal of physiology, 596(16), 3553-3566 (2018-06-05)
Prolonged exposure to vascular endothelial growth factor A (VEGF-A) inhibits agonist-mediated endothelial cell Ca2+ release and subsequent activation of intermediate conductance Ca2+ -activated K+ (IKCa ) channels, which underpins vasodilatation as a result of endothelium-dependent hyperpolarization (EDH) in mouse resistance
Guiyun Zhao et al.
Nature communications, 11(1), 1614-1614 (2020-04-03)
The heterocycle 1,2,3-triazole is among the most versatile chemical scaffolds and has been widely used in diverse fields. However, how nature creates this nitrogen-rich ring system remains unknown. Here, we report the biosynthetic route to the triazole-bearing antimetabolite 8-azaguanine. We
Massimiliano Marvasi et al.
AMB Express, 4, 42-42 (2014-07-06)
Biofilms in the industrial environment could be problematic. Encased in extracellular polymeric substances, pathogens within biofilms are significantly more resistant to chlorine and other disinfectants. Recent studies suggest that compounds capable of manipulating nitric oxide-mediated signaling in bacteria could induce
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