P1499
Pterostilbene
≥97% (HPLC), solid
Sinônimo(s):
Pterocarpus marsupium, 3,5-Dimethoxy-4′-hydroxystilbene, 4-[(1E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol
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About This Item
Fórmula empírica (Notação de Hill):
C16H16O3
Número CAS:
Peso molecular:
256.30
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
Nível de qualidade
Ensaio
≥97% (HPLC)
Formulário
solid
condição de armazenamento
protect from light
solubilidade
DMSO: >20 mg/mL
H2O: insoluble
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
COc1cc(OC)cc(\C=C\c2ccc(O)cc2)c1
InChI
1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
chave InChI
VLEUZFDZJKSGMX-ONEGZZNKSA-N
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Descrição geral
Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene), an antioxidant is an analogue of resveratrol. It is present in blueberries, tree wood and some types of grapes.
Aplicação
Pterostilbene has been used:
- to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway
- to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells)
- to study its effects on the cytotoxicity of 2-chloroethyl ethyl sulphide (CEES) in human epidermoid carcinoma cells (A-431) through MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide)viability assay
Ações bioquímicas/fisiológicas
Antioxidant, antiproliferative, apoptosis inducer, antihyperglycemic, antidiabetic.
Pterostilbene exhibits antineoplastic properties in some of the malignancies, hence it is considered as an active anticancer agent. It has the ability to stimulate apoptosis and block the viability of cell in estrogen-receptor positive and negative breast cancer cell lines.
Atenção
Air-sensitive
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Aquatic Chronic 2 - Eye Dam. 1
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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A novel combinatorial epigenetic therapy using resveratrol and pterostilbene for restoring estrogen receptor-alpha (ER alpha) expression in ER alpha-negative breast cancer cells
Kala R and Tollefsbol T O
PLoS ONE, 11(5), e0155057-e0155057 (2016)
Keitaro Hagiwara et al.
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Rei Wakimoto et al.
Anticancer research, 37(11), 6153-6159 (2017-10-25)
Although pterostilbene, a natural analog of resveratrol, has potent antitumor activity against several human cancer types, the possible inhibitory mechanisms against subtypes of human breast cancer with different hormone receptor and human epidermal growth factor receptor 2 (HER2) status remain
Wasamon Nutakul et al.
Journal of agricultural and food chemistry, 59(20), 10964-10970 (2011-09-23)
The effects of resveratrol and pterostilbene (two structurally related stilbene compounds) on three human colon cancer cells were systematically compared. Cell viability tests indicated that IC(50) values of pterostilbene were 2-5-fold lower than those of resveratrol in all three cancer
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