P1431
Calmodulin from bovine testes
BioUltra, ≥98% (SDS-PAGE), lyophilized powder, essentially salt free
Sinônimo(s):
CaM, Phosphodiesterase 3′:5′-cyclic nucleotide activator
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About This Item
Produtos recomendados
fonte biológica
bovine testis
Nível de qualidade
linha de produto
BioUltra
Ensaio
≥98% (SDS-PAGE)
forma
lyophilized powder
peso molecular
16.79 kDa
condição de armazenamento
(Keep container tightly closed in a dry and well-ventilated place)
técnica(s)
ligand binding assay: suitable
Impurezas
salt, essentially free
nº de adesão UniProt
aplicação(ões)
cell analysis
temperatura de armazenamento
−20°C
Informações sobre genes
cow ... CALM3(520277)
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Categorias relacionadas
Descrição geral
Research area: Cell Signaling
Calmodulin (CaM) is a Ca2+-sensor protein containing four EF-hand motifs that bind to four Ca2+ ions. It is found ubiquitously in all eukaryotes.
Calmodulin (CaM) is a Ca2+-sensor protein containing four EF-hand motifs that bind to four Ca2+ ions. It is found ubiquitously in all eukaryotes.
Aplicação
Calmodulin from bovine testes has been used:
- as a component of the reaction mixture in PhosphoSens assay to measure Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) substrate phosphorylation
- to generate standard curve for the determination of in situ calmodulin concentration in tissues
- as a ligand in radio-ligand binding for studying calmodulin affinity
Ações bioquímicas/fisiológicas
Calmodulin (CaM) aids in the Ca2+ signal transduction pathway in higher plants and animals. Ca2+ binding is required for CaM activation. Upon activation, CaM binds and activates numerous target proteins involved in a variety of cellular processes including regulation of plant metabolism, phytohormone signaling, ion transport, protein folding, protein phosphorylation and dephosphorylation, cell motility, exocytosis, and cytoskeletal assembly. In neurons, calcium-activated CaM helps in the regulation of glutamate receptors, modulation of proteins in signaling pathways, and regulation of voltage-gated calcium channels (VGCCs) activity.
Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.
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Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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