O4000

Oxythiamine chloride hydrochloride

≥95% (HPLC)

• Sinônimo(s): 5-(2-Hydroxyethyl)-3-(4-hydroxy-2-methyl-5-pyrimidinylmethyl)-4-methylthiazolium chloride
• Fórmula empírica (Notação de Hill): C₁₂H₁₆ClN₃O₂S · HCl
• Número CAS: 614-05-1
• Peso molecular: 338.25
• Número MDL: MFCD00050656
• Código UNSPSC: 12352116
• ID de substância PubChem: 24897990
• NACRES: NA.79

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥95% (HPLC)
• Formulário: powder
• técnica(s): HPLC: suitable
• cor: white to off-white
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CC(N1)=NC=C(C[N+]2=CSC(CCO)=C2C)C1=O.Cl.[Cl-]
• InChI: 1S/C12H16N3O2S.2ClH/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17;;/h5,7,16H,3-4,6H2,1-2H3,(H,13,14,17);2*1H
• chave InChI: QHUYPZVMEJLSEB-UHFFFAOYSA-N

Descrição

Descrição geral

Oxythiamine is a thiamine antimetabolite and the source through diet is by consuming acidic thiamine rich foods.

Aplicação

Oxythiamine chloride hydrochloride is suitable for use:

• as a reference standard for calibration curve generation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for oxythiamine pyrophosphate (OTPP) quantification in red blood cells
• as a thiamine transport inhibitor in human mammary epithelial cells (HMEC) and breast cancer cell lines
• in the synthesis of oxythiamineH picrolonate salt

Ações bioquímicas/fisiológicas

Oxythiamine (OT) is a thiamine antagonist. It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms, especially those involving metalloproteinases (MMP). It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression.

Oxythiamine inhibits Transketolase, the enzyme that controls the nonoxidative branch of the pentose phosphate pathway.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)