L4146
Leptin human
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Sinônimo(s):
OB
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About This Item
Produtos recomendados
recombinante
expressed in E. coli
Nível de qualidade
esterilidade
sterile; 0.2 μm filtered
Ensaio
≥97% (SDS-PAGE)
forma
lyophilized powder
potência
≤3.0 ng/mL ED50/EC50
peso molecular
predicted mol wt ~16 kDa
Impurezas
≤1.0 EU/μg endotoxin
nº de adesão UniProt
Condições de expedição
ambient
temperatura de armazenamento
−20°C
Informações sobre genes
human ... LEP(3952)
Descrição geral
The gene LEP (leptin) is mapped to human chromosome 7q31. It is a 16kDa peptide. Leptin is released in the circulation and goes to the CNS (central nervous system). In CNS, it works by associating with leptin receptor.
Aplicação
Leptin human has been used:
- to study the effect of leptin on ACAT1 (acyl-coenzyme A:cholesterol acyltransferase 1) expression and cholesterol efflux from primary cultured human macrophages
- to study the effect of leptin on expression of IGFBP2 (insulin growth factor binding protein 2) in skeletal muscle
- to study the effect of leptin on HLA-G (human leukocyte antigen G) expression in placental trophoblasts
- to study the effect of leptin on in vitro maturation, fertilization and development of horse oocytes after ICSI (intracytoplasmic sperm injection)
Ações bioquímicas/fisiológicas
Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo.
Human and mouse leptin share ~84% sequence identity.
Human and mouse leptin share ~84% sequence identity.
Leptin is believed to play a role in normal pregnancy development.
Mutations in LEP (leptin) are linked with type-2 diabetes. Presence of high levels of leptin in plasma is related to adiposity.
forma física
Lyophilized from a 0.2 μm filtered solution with 0.0045 mM NaHCO3
Nota de análise
The biological activity is measured by its ability to induce proliferation of leptin-dependent human OB-R transfected murine BAF3 cells.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Reza Meshkani et al.
Clinical laboratory, 62(1-2), 89-96 (2016-03-26)
The leptin (LEP G2548A) and leptin receptor (LEPR Q223R) gene polymorphisms have been variably associated with type 2 diabetes (T2D) in different populations. In this study we hypothesized that these variants might be associated with T2D and related metabolic traits
Eiji Kashiwagi et al.
American journal of translational research, 12(6), 3033-3045 (2020-07-14)
Adipocytokines such as leptin and adiponectin have functions in metabolism as well as the development and progression of various types of malignancies. However, little is known about their role in bladder cancer. In this study, we investigated whether leptin, adiponectin
Leptin action in normal and pathological pregnancies
Peerez PA, et al.
Journal of Cellular and Molecular Medicine, 22(2), 716-716 (2018)
Elisabetta Trevellin et al.
Oncotarget, 6(13), 11203-11215 (2015-04-11)
Obesity is associated with cancer risk in esophageal adenocarcinoma (EAC). Adipose tissue directly stimulates tumor progression independently from body mass index (BMI), but the mechanisms are not fully understood. We studied the morphological, histological and molecular characteristics of peritumoral and
Masafumi Kurajoh et al.
Cardiovascular diabetology, 14, 117-117 (2015-09-05)
It has been shown that visceral fat accumulation is associated with autonomic dysfunction, though the precise mechanism remains unclear. A recent basic study found that leptin can directly modulate autonomic function through the dorsomedial hypothalamus in relation to obesity. Here
Artigos
Lipid Induced Insulin Resistance
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