M2574

Meropenem trihydrate

≥98% (HPLC), powder, antibacterial agent

• Sinônimo(s): (1R,5S,6S)-2-[(3S,5S)-5-(dimethylaminocarbonyl)pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid trihydrate
• Fórmula empírica (Notação de Hill): C₁₇H₂₅N₃O₅S · 3H₂O
• Número CAS: 119478-56-7
• Peso molecular: 437.51
• Número MDL: MFCD08600005
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nome do produto: Meropenem trihydrate, ≥98% (HPLC)
• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: white to off-white
• solubilidade: DMSO: ≥20 mg/mL
• originador: AstraZeneca
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O.O.O.C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)=C(N2C1=O)C(O)=O
• InChI: 1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1.../s1
• chave InChI: CTUAQTBUVLKNDJ-OBZXMJSBSA-N

Descrição

Descrição geral

Meropenem trihydrate (MRP) belongs to the carbapenem group of compounds. It is susceptible to degradation at high temperature and humidity. It is soluble in methanol-water or acetone-water combinations. It is used as an antibacterial agent for treating meningitis and pneumonia.

Aplicação

Meropenem trihydrate has been used in the

• antibiotic susceptibility testing of E coli isolates from harbor estuary sediment samples
• in the bacterial killing assay and for screening antibiotic resistance of cystic fibrosis patient′s sputum based Staphylococcus aureus transformed macrophages in phagocyte infection
• for screening Enterococcus faecalis from human bile

Ações bioquímicas/fisiológicas

Meropenem trihydrate is an ultra-broad spectrum beta-lactam antibiotic active against both Gram-positive and Gram-negative bacteria.

Características e benefícios

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H317,H334
• Declarações de precaução: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Classificações de perigo: Resp. Sens. 1 - Skin Sens. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable