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I8000

Sigma-Aldrich

2-Iodosobenzoic acid

≥98% (TLC)

Sinônimo(s):

IBA

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About This Item

Fórmula linear:
OIC6H4CO2H
Número CAS:
304-91-6
Peso molecular:
264.02
Beilstein:
1939973
Número CE:
206-159-4
Número MDL:
MFCD00002401
Código UNSPSC:
12352209
ID de substância PubChem:
24896131
NACRES:
NA.26

product name

2-Iodosobenzoic acid,

Ensaio

≥98% (TLC)

forma

powder

cor

white to off-white

pf

230 °C (dec.) (lit.)

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

OC(=O)c1ccccc1[I]=O

InChI

1S/C7H5IO3/c9-7(10)5-3-1-2-4-6(5)8-11/h1-4H,(H,9,10)

chave InChI

IFPHDUVGLXEIOQ-UHFFFAOYSA-N

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Aplicação

For cleavage of tryptophanyl peptide bonds.

Ações bioquímicas/fisiológicas

2-Iodosobenzoic acid (IBA) may be used to study enzyme structure and activity. IBA is used as an oxidant which oxidizes vicinal sulfhydryls to disulfides (cysteine residues) within enzymes leading to their inactivation or conformational changes. IBA is also used to cleave tryptophanyl peptide bonds.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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J M Souza et al.
Archives of biochemistry and biophysics, 360(2), 187-194 (1998-12-16)
Rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was inactivated by peroxynitrite under biologically relevant conditions. The decrease of enzymatic activity followed an exponential function, and the concentration of peroxynitrite needed to inactivate 50% of 7 microM GAPDH (IC50) was 17 microM. Hydroxyl
T Kleinschmidt et al.
Biological chemistry Hoppe-Seyler, 370(8), 839-845 (1989-08-01)
The monomeric hemoglobin fractions of Chironomus thummi thummi (CTT) and Chironomus thummi piger (CTP) differ in the ratio of their components. The determination of the primary structure of the component CTP III was achieved by automatic Edman degradation of the
S Stoeva et al.
Biochemistry, 29(2), 527-534 (1990-01-16)
The amino acid sequence of the neutral zinc protease from Bacillus mesentericus strain 76 (MCP 76) has been determined by using peptides derived from digests with trypsin, chymotrypsin, and cyanogen bromide and from cleavage with o-iodosobenzoic acid. The peptides were
R J Duhé et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(1), 126-131 (1998-02-21)
The activation of Janus kinases (JAKs) is crucial for propagation of the proliferative response initiated by many cytokines. The proliferation of various cell lines, particularly those of hematopoietic origin, is also modulated by mediators of oxidative stress such as nitric
D Beale
The International journal of biochemistry, 21(5), 549-554 (1989-01-01)
1. Tryptic cleavage sites in bovine secretory component (SC) which become inaccessible when SC is bound to IgA dimer remained inaccessible at 60 degrees C and in 4 M urea at 37 degrees C. 2. This suggests the presence of
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