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Documentos Principais

H4036

SAFC

L-Histidina

Fabricação farmacêutica

Sinônimo(s):

Ácido L-α-amino-β-(4-imidazolil)propiônico

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About This Item

Fórmula empírica (Notação de Hill):
C6H9N3O2 · HCl · H2O
Número CAS:
Peso molecular:
209.63
Beilstein:
4168261
Número MDL:
Código UNSPSC:
12352209
eCl@ss:
32160406
NACRES:
NA.26

fonte biológica

non-animal source

Nível de qualidade

Ensaio

≥98.5%

Formulário

powder

fabricante/nome comercial

Ajinomoto

técnica(s)

cell culture | mammalian: suitable

Impurezas

endotoxin, heavy metals, residual solvents, tested

pf

254 °C (dec.) (lit.)

solubilidade

H2O: 50 mg/mL

aplicação(ões)

pharmaceutical (small molecule)

atividade externa

cytotoxicity, tested

cadeia de caracteres SMILES

O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1

chave InChI

CMXXUDSWGMGYLZ-XRIGFGBMSA-N

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Descrição geral

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

Aplicação

L-Histidine, an essential amino acid. It is used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. L-Histidine monohydrochloride monohydrate is a modified version of L-Histidine with improved solubility.

Informações legais

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


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Sigma-Aldrich

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Sacarose EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, NF

SAFC

1.00892

Sacarose

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The journal of physical chemistry. B, 123(27), 5690-5699 (2019-07-02)
Protein/ice interactions are investigated by a novel method based on measuring the characteristic features of X-ray diffraction (XRD) patterns of hexagonal ice (Ih). Aqueous solutions of four proteins and other solutes are studied using high-resolution synchrotron XRD. Two pharmaceutical proteins
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Neurochemistry international, 85-86, 31-39 (2015-05-06)
The effect of reserpine on histamine (HA) and tele-methylhistamine (N(τ)-MHA) in hypothalamus and cortex of rats was analyzed and compared to catecholamines. IP injection of reserpine (5 mg/kg) confirmed the effectiveness of reserpine treatment on noradrenaline and dopamine levels. Our in-vitro
Verena Saller et al.
Journal of pharmaceutical sciences, 104(4), 1440-1450 (2015-01-22)
In a typical manufacturing setup for biopharmaceutical drug products, the fill and dosing pump is placed after the final sterile filtration unit in order to ensure adequate dispensing accuracy and avoid backpressure peaks. Given the sensitivity of protein molecules, peristaltic
Aldo Roda et al.
The Analyst, 139(24), 6494-6501 (2014-10-25)
Increasingly, smartphones are used as portable personal computers, revolutionizing communication styles and entire lifestyles. Using 3D-printing technology we have made a disposable minicartridge that can be easily prototyped to turn any kind of smartphone or tablet into a portable luminometer
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Recent developments in detection and enumeration of histamine-producing bacteria (HPB) have created powerful molecular-based tools to better understand the presence of spoilage bacteria and conditions, resulting in increased risk of scombrotoxin fish poisoning. We examined 235 scombrotoxin-forming fish from the

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