A3940

1-Aminobenzotriazole

≥98% (TLC), powder, cytochrome P450 inhibitor

• Sinônimo(s): 1-Benzotriazolamine, ABT
• Fórmula empírica (Notação de Hill): C₆H₆N₄
• Número CAS: 1614-12-6
• Peso molecular: 134.14
• Beilstein: 607843
• Número MDL: MFCD00132902
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278226
• NACRES: NA.77

Propriedades

• product name: 1-Aminobenzotriazole,
• Ensaio: ≥98% (TLC)
• Nível de qualidade: 200
• forma: powder
• pontuação do produto alternativo mais ecológico: old score: 93; new score: 46; Find out more about DOZN™ Scoring
• características do produto alternativo mais ecológico: Waste Prevention; Safer Solvents and Auxiliaries; Inherently Safer Chemistry for Accident Prevention; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• pf: 81-84 °C (lit.)
• solubilidade: ethanol: 49-51 mg/mL, clear, pale yellow to yellow
• categoria alternativa mais ecológica: , Re-engineered
• cadeia de caracteres SMILES: Nn1nnc2ccccc12
• InChI: 1S/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2
• chave InChI: JCXKHYLLVKZPKE-UHFFFAOYSA-N
• Informações sobre genes: human ... CYP1A2(1544)

Descrição

Descrição geral

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives. This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Safer Solvents and Auxiliaries” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

Aplicação

1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H₂O₂-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.

Ações bioquímicas/fisiológicas

1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.

Suicide inhibitor of cytochrome P450 and chloroperoxidase.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves