PHR1648

Omeprazole Related Compound A

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinônimo(s): Omeprazole sulfone, 5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfonyl]-1H-benzimidazole, 5-Methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl}-1H-benzimidazole, Omeprazole sulphone
• Fórmula empírica (Notação de Hill): C₁₇H₁₉N₃O₄S
• Número CAS: 88546-55-8
• Peso molecular: 361.42
• Beilstein: 8347309
• Número MDL: MFCD00869772
• Código UNSPSC: 41116107
• ID de substância PubChem: 329823531
• NACRES: NA.24

Propriedades

• grau: certified reference material; pharmaceutical secondary standard
• Nível de qualidade: 300
• Agency: traceable to Ph. Eur. O0151000; traceable to USP 1478516
• família API: omeprazole
• Certificado de análise (CofA): current certificate can be downloaded
• embalagem: pkg of 30 mg
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• aplicação(ões): pharmaceutical (small molecule)
• Formato: neat
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=S(C1=NC2=CC(OC)=CC=C2N1)(CC3=NC=C(C)C(OC)=C3C)=O
• InChI: 1S/C17H19N3O4S/c1-10-8-18-15(11(2)16(10)24-4)9-25(21,22)17-19-13-6-5-12(23-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
• chave InChI: IXEQEYRTSRFZEO-UHFFFAOYSA-N

Descrição

Descrição geral

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

It is an impurity of the substituted benzimidazole― omeprazole, that belongs to the class of proton pump inhibitors (PPIs). Omeprazole inhibits the secretion of gastric juice by inhibiting the activity of the enzyme H⁺/K⁺-ATPase (Hydrogen-Potassium Adenosine Triphosphates). Hence it is used widely for the treatment of diseases caused by excess secretion of gastric juices.

Aplicação

This pharmaceutical secondary standard can also be used as follows:

• Analysis of omeprazole tablets for the separation and detection of omeprazole and its related impurities by reversed-phase high-performance liquid chromatographic (RP-HPLC) method
• Determination of omeprazole and its 11 related impurities in pharmaceutical formulations by RP-HPLC method based on quality-by-design approach (QbD)
• Development of an ultra-high performance liquid chromatography-time of flight-mass spectrometry (UHPLC-TOF-MS) based method to estimate omeprazole and its related impurities in pharmaceutical formulations
• Separation and detection of omeprazole and its metabolites in human urine samples by capillary zone electrophoresis (CZE) combined with UV-Visible detector
• Estimation of related impurities of omeprazole and domperidone in their combined dosage form using the RP-HPLC method

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC3168 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produtos recomendados

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Informações de segurança

• Pictogramas: GHS07,GHS09
• Palavra indicadora: Warning
• Frases de perigo: H302,H411
• Declarações de precaução: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Chronic 2
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable