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29992

Sigma-Aldrich

Acetato de DL-α-tocoferol

tested according to Ph. Eur.

Sinônimo(s):

Acetato de all-rac-α-tocoferil, Acetato de vitamina E

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About This Item

Fórmula empírica (Notação de Hill):
C31H52O3
Número CAS:
7695-91-2
Peso molecular:
472.74
Beilstein:
97512
Número CE:
231-710-0
Número MDL:
MFCD00072042
Código UNSPSC:
12352209
ID de substância PubChem:
329753404
NACRES:
NA.26

fonte biológica

synthetic

Nível de qualidade

200

Agency

USP/NF
tested according to Ph. Eur.

Ensaio

96.5-102.0%

forma

liquid

densidade

0.96 g/mL at 20 °C (lit.)

aplicação(ões)

cell analysis
pharmaceutical (small molecule)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

chave InChI

ZAKOWWREFLAJOT-CEFNRUSXSA-N

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Descrição geral

α-Tocopherol is a form of vitamin E. Vitamin E can be obtained through dietary sources. RRR‐α‐tocopherol is a natural form of α-Tocopherol.

Aplicação

DL-alpha-Tocopherol acetate was used as a vitamin E supplement for studying whether the addition of an antioxidant or vitamin E in the diet of rats with dextran sulfate sodium (DSS)-induced colitis can reduce detrimental impact of inflammatory bowel disease.

Ações bioquímicas/fisiológicas

α-Tocopherol is also known as a radical-chain breaker due to its anti-oxidant property.
Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by Homosapiens. DL-α-Tocopherol acetate can inhibit oxidation of linoleate.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

No data available

Ponto de fulgor (°C)

No data available

Equipamento de proteção individual

Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
BCCG3547
BCCF5342
BCCF0806
BCCD1282
BCCC3045

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Supelco

Supelco

V-033

Tocopheryl acetate (Vitamin E acetate) solution

(+)-α-Tocopherol acetate BioReagent, suitable for insect cell culture, ~1360 IU/g

Sigma-Aldrich

T1157

(+)-α-Tocopherol acetate

(±)-α-Tocoferol European Pharmacopoeia (EP) Reference Standard

T1550000

(±)-α-Tocoferol

(±)-α-Tocoferol synthetic, ≥96% (HPLC)

Sigma-Aldrich

T3251

(±)-α-Tocoferol

Vitamin E acetate-(trimethyl-d9) 98 atom % D, 98% (CP)

Sigma-Aldrich

615366

Vitamin E acetate-(trimethyl-d9)

(+)-α-Tocopherol from vegetable oil, Type V, ~1000 IU/g

Sigma-Aldrich

T3634

(+)-α-Tocopherol

(+)-α-Tocopherol Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000 IU/g

Sigma-Aldrich

T1539

(+)-α-Tocopherol

alpha-Tocopherol stereoisomers
Jensen S K and Lauridsen C
Vitamins and Hormones, 76(3), 281-308 (2007)
Julie Carrier et al.
The Journal of nutrition, 132(10), 3146-3150 (2002-10-09)
Inflammatory bowel disease is often associated with iron deficiency anemia and oral iron supplementation may be required. However, iron may increase oxidative stress through the Fenton reaction and thus exacerbate the disease. This study was designed to determine in rats
S Grossman et al.
The International journal of biochemistry, 16(3), 281-289 (1984-01-01)
The formation of alpha-tocopherol--lipoxygenase complex was elucidated using immobilized affinity purified soybean lipoxygenase and [D-3H]alpha-tocopherol. The alpha-tocopherol--lipoxygenase complex did not dissociate on addition of linoleic acid. Iodoacetate modified immobilized lipoxygenase did not form the complex with alpha-tocopherol. Lipoxygenase attached to
Molecular mechanism of alpha-tocopherol action
Azzi A
Free radical biology & medicine, 43(1), 16-21 (2007)
Absorption, transport, and tissue delivery of vitamin E
Rigotti A
Molecular Aspects of Medicine, 28(5-6), 423-436 (2007)
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