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T1157

Sigma-Aldrich

(+)-α-Tocopherol acetate

BioReagent, suitable for insect cell culture, ~1360 IU/g

Sinônimo(s):

Vitamin E acetate

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About This Item

Fórmula empírica (Notação de Hill):
C31H52O3
Número CAS:
58-95-7
Peso molecular:
472.74
Número CE:
200-405-4
Número MDL:
MFCD00072052
Código UNSPSC:
12352205
eCl@ss:
34058007
ID de substância PubChem:
24899940
NACRES:
NA.75

fonte biológica

plant

Nível de qualidade

200

descrição

Synthesized from natural α-tocopherol

linha de produto

BioReagent

Formulário

liquid (or semi-solid)

atividade específica

~1360 IU/g

peso molecular

Mw 472.74 g/mol

purificado por

crystallization

técnica(s)

cell culture | insect: suitable

cor

white to yellow

solubilidade

chloroform: soluble 50 mg/mL, clear, colorless to yellow

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

chave InChI

ZAKOWWREFLAJOT-CEFNRUSXSA-N

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Descrição geral

α-Tocopherol acetate is a semisynthetic acetate ester of naturally occurring α-tocopherol.

Aplicação

(+)-α-Tocopherol acetate has been used:
  • as a supplement in the human embryonic kidney cells (HEK 293) to assess its impact on cell growth
  • as a component of Dulbecco′s Modified Eagle Medium/Nutrient Mixture F-12 (DMEM/F12) for immortalized chondrocyte cell line
  • as a component of serum-free medium for human colon tissue organ culture
  • to test its antioxidant effects on cow articular chondrocytes

Use in insect cell culture applications as an antioxidant.

Ações bioquímicas/fisiológicas

α-Tocopherol acetate or vitamin E-acetate has antioxidant properties and reduces lipid peroxidation. However, vitamin E acetate on pyrolysis leads to the generation of carcinogens like alkenes and benzenes.

Atenção

Since the M.P. is about 25 °C this preparation is usually an oil. Does not air oxidize.

Frases de perigo

H413

Declarações de precaução

P273 - P501

Classificações de perigo

Aquatic Chronic 4

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Equipamento de proteção individual

Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
SLCL1318
SLCH1778
SLBZ9611
SLBZ4654
SLBX4005

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Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 46(2), 114-122 (2009-11-17)
Normal and neoplastic human colon tissue obtained at surgery was used to establish conditions for organ culture. Optimal conditions included an atmosphere of 5% CO2 and 95% O2; tissue partially submerged with mucosa at the gas interface; and serum-free medium
Optimization of HEK 293 cell growth by addition of non-animal derived components using design of experiments.
Laura Cervera et al.
BMC proceedings, 5 Suppl 8, P126-P126 (2012-03-01)
Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 47(1), 32-38 (2010-11-26)
We have recently shown that a multi-mineral extract from the marine red algae, Lithothamnion calcareum, suppresses colon polyp formation and inflammation in mice. In the present study, we used intact human colon tissue in organ culture to compare responses initiated
Dan Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(12), 6349-6355 (2020-03-12)
A combined analytical, theoretical, and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in pulmonary injuries associated with using
Brandon Mapes et al.
Physiological genomics, 46(8), 302-308 (2014-02-20)
1α,25-Dihydroxyvitamin D3 [1α,25(OH)2D3] is a steroid hormone derived from circulating 25(OH) vitamin D [25(OH)D] with chemopreventive effects in colorectal cancer. 1α,25(OH)2D3 acts through transcriptional mechanisms; however, our understanding of vitamin D transcriptional responses in the colon is derived from studies
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