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258024

Sigma-Aldrich

(±)-α-Tocoferol

≥95.5%

Sinônimo(s):

DL-all-rac-α-Tocoferol, Vitamina E

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About This Item

Fórmula empírica (Notação de Hill):
C29H50O2
Número CAS:
10191-41-0
Peso molecular:
430.71
Beilstein:
94012
Número CE:
233-466-0
Número MDL:
MFCD00006848
Código UNSPSC:
12352205
eCl@ss:
34058016
ID de substância PubChem:
57648149
NACRES:
NA.28

fonte biológica

synthetic

Nível de qualidade

200

Ensaio

≥95.5%

forma

liquid

técnica(s)

HPLC: suitable

cor

faint brown to brown
 yellow to very dark yellow

densidade

0.950 g/mL at 20 °C (lit.)

aplicação(ões)

cell analysis

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1

InChI

1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3

chave InChI

GVJHHUAWPYXKBD-UHFFFAOYSA-N

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Descrição geral

α-Tocopherol is the active form of vitamin E. It functions as an hydroperoxyl radical scavenger and protects the organism from oxidative damage. α-Tocopherol plays a crucial role in cell signalling and regulating immune responses. α-Tocopherol deficiency is associated with abetalipoproteinemia, cystic fibrosis and celiac disease. It has antiproliferative effects. It inhibits arsenite-induced damage of human fibroblasts.

Aplicação

α-Tocopherol has been used:
  • as a standard to determine its concentration by reverse-phase high-performance liquid chromatography
  • to study its rescue effects on chlorine dioxide (ClO2) cytotoxicity
  • to assess its protective effects on acetaminophen (APAP)-mediated liver damage

Ações bioquímicas/fisiológicas

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

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Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H317

Classificações de perigo

Skin Sens. 1

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Equipamento de proteção individual

Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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(±)-α-Tocoferol Pharmaceutical Secondary Standard; Certified Reference Material

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SAFC

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Oxidative stress induced by chlorine dioxide as an insecticidal factor to the Indian meal moth, Plodia interpunctella
Kumar S, et al
Pesticide Biochemistry and Physiology, 124, 48-59 (2015)
Medical Countermeasures?Chelation Therapy
Handbook of Arsenic Toxicology, 589-626 (2015)
Sarawoot Palipoch et al.
BMC complementary and alternative medicine, 14, 111-111 (2014-03-29)
cis-Diammineplatinum (II) dichloride (cisplatin) is the important anti-cancer agent useful in treatment of various cancers. Unfortunately, it can produce unwanted side effects in various tissues, including the liver. The present study investigated the possible protective role of curcumin and α-tocopherol
Nutritional deficiencies and syndromes associated with alcoholism
Textbook of Clinical Neurology (Third Edition), 897-917 (2007)
Effect of vitamin E on oxidative stress level in blood, synovial fluid, and synovial tissue in severe knee osteoarthritis: a randomized controlled study
Tantavisut S, et al.
BMC Musculoskelet. Disord., 18(1), 281-281 (2017)
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