T3634

(+)-α-Tocopherol

from vegetable oil, Type V, ~1000 IU/g

• Sinônimo(s): 2,5,7,8-Tetramethyl-2-(4′,8′,12′-trimethyltridecyl)-6-chromanol, 5,7,8-Trimethyltocol, D-α-Tocopherol, Vitamin E
• Fórmula empírica (Notação de Hill): C₂₉H₅₀O₂
• Número CAS: 59-02-9
• Peso molecular: 430.71
• Beilstein: 4712525
• Número CE: 200-412-2
• Número MDL: MFCD00072045
• Código UNSPSC: 12352205
• eCl@ss: 34058016
• ID de substância PubChem: 24900154
• NACRES: NA.79

Propriedades

• fonte biológica: vegetable oil
• Nível de qualidade: 200
• tipo: Type V
• Formulário: viscous liquid
• atividade específica: ~1000 IU/g
• cor: clear yellow to red
• índice de refração: n20/D 1.505 (lit.)
• p.e.: 200-220 °C/0.1 mmHg (lit.)
• densidade: 0.95 g/mL at 25 °C (lit.)
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1
• InChI: 1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
• chave InChI: GVJHHUAWPYXKBD-IEOSBIPESA-N

Descrição

Descrição geral

α-Tocopherol is synthesized from γ-tocopherol by the action of enzyme γ-tocopherol methyltransferase. It is the major form of Vitamin E in human plasma. It is present in sunflower seed oil.

Aplicação

(+)-α-Tocopherol has been used:

• as a food supplement for juvenile cobia fish
• to evaluate its protective effect on bisphenol A induced oxidative stress in rats
• to test its chemopreventive efficacy in estrogen-mediated mammary cancer rats

Ações bioquímicas/fisiológicas

α-Tocopherol is essential for the photosynthesis in Synechocystis sp. strain PCC 6803. Supplementation with α-Tocopherol decreases lipid peroxidation and platelet aggregation. It inhibits protein kinase C and may play key role in gene regulation.

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

Embalagem

Packaged under argon in a sealed ampule.

Outras notas

Mixed constitutional (α, β, γ, δ) isomers.

Qualidade

Approx. 670 mg D-α-tocopherol per gram. The non-α content is typically between 5-35 mg/g

Atenção

Subject to air oxidation.

propriedades físicas

This product is miscible with chloroform or ethanol. It is practically insoluble in water but it is miscible with ether, acetone, and vegetable oils. It is unstable to alkaline conditions.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 230.0 °F - closed cup
• Ponto de fulgor (°C): 110 °C - closed cup
• Equipamento de proteção individual: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)