MABE282
Anti-c-Myc Antibody, clone 9E10
clone 9E10, from mouse
Sinônimo(s):
Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, HLHe39, Proto-oncogene c-Myc, Transcription factor p64
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
9E10, monoclonal
reatividade de espécies
human
técnica(s)
ChIP: suitable
western blot: suitable
Isotipo
IgG1κ
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... MYC(4609)
Descrição geral
c-Myc (bHLHe39) is a transcription factor that regulates the expression of multiple genes involved in apoptosis, cell differentiation and cell proliferation. Active c-Myc is coupled to the MAX protein via c-Myc’s C-terminal helix-loop-helix leucine zipper (bHLHLZ) domain. The c-Myc-MAX heterodimer also interacts with a number of other transcription-related proteins including TRRAP, p107 and Miz-1, and c-Myc-MAX may indirectly regulate histone acetylases involved in chromatin remodeling to increase accessibility of transcriptional complexes to target DNA sequences. The expression of c-Myc is controlled by growth factors. Several studies have reported abnormal expression of c-Myc in various cancers including Burkitt’s lymphoma.
Imunogênio
Linear peptide corresponding to human c-Myc.
Aplicação
Anti-c-Myc Antibody, clone 9E10 is a Mouse Monoclonal Antibody for detection of c-Myc also known as Myc proto-oncogene protein, HLHe39, Transcription factor p64 & has been validated in WB, ChIP.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair
Cell Cycle, DNA Replication & Repair
Western Blot Analysis: A representative lot from an independent laboratory detected c-Myc in various cell lysates (Evan, G. I., et al. (1985). Mol Cell Biol. 5(12):3610-3616).
Chromatin Immunoprecipitation Analysis: A representative lot from an independent laboratory detected c-Myc in ChIP (Sanyal, K., et al. (2004). Proc Natl Acad Sci USA. 101(31):11374-11379).
Chromatin Immunoprecipitation Analysis: A representative lot from an independent laboratory detected c-Myc in ChIP (Sanyal, K., et al. (2004). Proc Natl Acad Sci USA. 101(31):11374-11379).
Qualidade
Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected c-Myc in 10 µg of HeLa cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected c-Myc in 10 µg of HeLa cell lysate.
Descrição-alvo
~51 kDa observed. Uniprot describes two isoforms at ~49 kDa and ~51 kDa
forma física
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Armazenamento e estabilidade
Stable for 1 year at 2-8°C from date of receipt.
Nota de análise
Control
HeLa cell lysate
HeLa cell lysate
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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