M5546
Monoclonal Anti-c-Myc antibody produced in mouse
clone 9E10, ascites fluid
Sinônimo(s):
Anti-c-Myc
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
ascites fluid
tipo de produto de anticorpo
primary antibodies
clone
9E10, monoclonal
contém
15 mM sodium azide
reatividade de espécies
human
técnica(s)
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 1:100 using c-myc tagged fusion protein
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... MYC(4609)
Procurando produtos similares? Visita Guia de comparação de produtos
Descrição geral
MYC (MYC proto-oncogene) is a transcriptional factor and oncoprotein. c-myc is a member of MYC gene family. It is located on human chromosome 8q24. c-Myc gene codes for basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor.
Monoclonal Anti-c-myc (mouse IgG1 isotype) is derived from the 9E10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice.
Monoclonal Anti-c-myc (mouse IgG1 isotype) is derived from the 9E10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice.
c-Myc is a transcription factor which is over-expressed in a wide range of cancers.
Especificidade
Recognizes both N- terminal and C-terminal c-Myc tagged proteins.
Imunogênio
synthetic peptide of the human p62c-Myc protein.
Aplicação
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Monoclonal anti-c-Myc antibody produced in mouse has been used for Western blotting and immunohistochemistry.
Monoclonal Anti-c-Myc antibody has also been used in:
Monoclonal Anti-c-Myc antibody has also been used in:
- the detection of horseradish peroxidase conjugate in phosphate buffered saline tween-20 (PBST) and 65-kDa mannoprotein (MP65) Dabs
- immunoblotting
- immunoprecipitation
- biochemical and histological studies
Ações bioquímicas/fisiológicas
The cellular myelocytomatosis (c-myc) oncogene plays a major role in cellular proliferation, differentiation and apoptosis. It acts as a transcriptional regulator of gene expression. MYC (MYC proto-oncogene) may be essential for cancer initiation, promotion and therapy resistance. Overexpression of MYC in DLBCL (diffuse large B-cell lymphoma) results in the poor outcome and invasive treatment, when medicated with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP).
c-Myc is a regulator of the cell cycle and aids in the growth of tumors in the liver. Translocations in the gene encoding it have been shown to be linked to Burkitt lymphoma. It has been studied that c-Myc targets many protein-coding genes which enhances the oncogenic properties of c-Myc.
forma física
The product is provided as ascites fluid with 15 mM sodium azide as a preservative.
Armazenamento e estabilidade
For continuous use, store at 2-8 °C for a maximum of one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Nº do produto
Descrição
Preços
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression.
Baudino TA, et al.
Genes & Development, 16(19), 2530-2543 (2002)
HIF-2α promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.
Gordan JD, et al.
Cancer Cell, 11(4), 335-347 (2007)
Basis for the isoform-specific interaction of myosin phosphatase subunits protein phosphatase 1c β and myosin phosphatase targeting subunit 1.
Scotto-Lavino E, et al.
The Journal of Biological Chemistry, 285(9), 6419-6424 (2010)
MAPK signal pathways in the regulation of cell proliferation in mammalian cells.
Zhang W and Liu HT
Cell Research, 12(1), 9-9 (2002)
Regulation of Apobec3F and human immunodeficiency virus type 1 Vif by Vif-Cul5-ElonB/C E3 ubiquitin ligase.
Liu B, et al.
Journal of Virology, 79(15), 9579-9587 (2005)
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