474788

MG-132

≥95% (HPLC), liquid, proteasome inhibitor, Calbiochem^®

• Sinônimo(s): InSolution MG-132 in EtOH, ≥95% by HPLC, Proteasome Inhibitor XI
• Fórmula empírica (Notação de Hill): C₂₆H₄₁N₃O₅
• Peso molecular: 475.62
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nome do produto: MG-132 in EtOH, ≥95% by HPLC, InSolution, ≥95%, reversible proteasome inhibitor
• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• Formulário: liquid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• Condições de expedição: ambient
• temperatura de armazenamento: −70°C

Descrição

Descrição geral

Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM).Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κBactivation (IC₅₀ = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available.

Ações bioquímicas/fisiológicas

Cell permeable: yes

K_i = 4 nM for proteasomal inhibition

Reversible: yes

Secondary Target
IKK

Embalagem

Packaged under inert gas

Advertência

Toxicity: Flammable (J)

Reconstituição

Following initital thaw, aliquot and freeze (-70°C).

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS02,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H225,H319
• Declarações de precaução: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Flam. Liq. 2
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): 53.6 °F - closed cup - Information refers to the main ingredient.
• Ponto de fulgor (°C): 12 °C - closed cup - Information refers to the main ingredient.