235135

Corticosterone

≥95% (HPLC), crystalline powder, corticosteroid hormone, Calbiochem

• Sinônimo(s): Corticosterone, (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione, Reichstein’s substance H
• Fórmula empírica (Notação de Hill): C₂₁H₃₀O₄
• Número CAS: 50-22-6
• Peso molecular: 346.46
• Número MDL: MFCD00037715
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• product name: Corticosterone, Corticosteroid hormone synthesized in response to stress.
• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: crystalline powder
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• cor: off-white; white to tan
• solubilidade: ethanol: 50 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 10-30°C
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• chave InChI: OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Descrição

Descrição geral

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered expression which eventually affects ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered genomic expression. Steroid-induced changes in protein synthesis eventually affect ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
Mineralocorticoid and glucocorticoid receptors

Product does not compete with ATP.

Reversible: no

Advertência

Toxicity: Carcinogenic / Teratogenic (D)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Garvy, B.A., et al. 1993. Immunology80, 587.
DeKloet, E.R. 1992. Ann. N.Y. Acad. Sci.663, 357.
Joels, M., and deKloet, E.R. 1992. Trends Neurosci.15, 25.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3