27840

Corticosterone

≥98.5% (HPLC)

• Sinônimo(s): 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
• Fórmula empírica (Notação de Hill): C₂₁H₃₀O₄
• Número CAS: 50-22-6
• Peso molecular: 346.46
• Beilstein: 2339601
• Número CE: 200-019-6
• Número MDL: MFCD00037715
• Código UNSPSC: 12352211
• ID de substância PubChem: 57648276
• NACRES: NA.77

Propriedades

• fonte biológica: synthetic
• Nível de qualidade: 200
• Ensaio: ≥98.5% (HPLC)
• forma: powder or crystals
• atividade óptica: [α]20/D +223±3°, c = 1% in ethanol
• pf: 179-183 °C (lit.); 179-183 °C
• grupo funcional: ketone
• cadeia de caracteres SMILES: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• chave InChI: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• Informações sobre genes: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

Descrição

Descrição geral

Corticosterone (Cort) is a glucocorticoid hormone. It is also the principal hormone that mediates stress responses in birds. It is the primary adrenal cortical steroid in rat plasma. The influence of maternal Cort exposure on the developing placenta has been studied in a mouse model.

Aplicação

Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune suppression experiment.

Ações bioquímicas/fisiológicas

Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Nota de preparo

Corticosterone is soluble in chloroform and ethanol.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves