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Supelco

Corticosterone

VETRANAL®, analytical standard

Sinônimo(s):

11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H

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About This Item

Fórmula empírica (Notação de Hill):
C21H30O4
Número CAS:
50-22-6
Peso molecular:
346.46
Beilstein:
2339601
Número CE:
200-019-6
Número MDL:
MFCD00037715
Código UNSPSC:
41116107
ID de substância PubChem:
329757087
NACRES:
NA.24

grau

analytical standard

Nível de qualidade

100

linha de produto

VETRANAL®

Ensaio

≥98% (HPLC)

prazo de validade

limited shelf life, expiry date on the label

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

pf

179-183 °C (lit.)

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

cadeia de caracteres SMILES

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

chave InChI

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

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Descrição geral

Corticosterone is one of the principal steroids secreted by the rat adrenal gland and found in rat plasma.

Aplicação

Corticosterone may be used as a reference standard in the determination of corticosterone in plasma samples using high-performance liquid chromatography (HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Informações legais

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
BCCG5805
BCCC8243
BCBT8610
SZBC066XV
SZB7141XV

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Cortisone ≥95%

Sigma-Aldrich

C2755

Cortisone

11-Deoxycorticosterone solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

D-105

11-Deoxycorticosterone solution

Determination of plasma corticosterone using high-performance liquid chromatography.
Woodward HJC and Emery WP
Journal of Chromatography. B, Biomedical Sciences and Applications, 419(2), 280-284 (1987)
The estimation of small amounts of corticosterone in rat plasma.
Zenker N and Bernstein ED
The Journal of Biological Chemistry, 231(2), 695-701 (1958)
Kirsten R Jacobsen et al.
Comparative medicine, 63(2), 105-113 (2013-04-16)
Laboratory mice constitute an extensively used model to study the pathologic and functional outcomes of cerebral ischemic stroke. The middle cerebral artery occlusion (MCAO) model requires surgical intervention, which potentially can result in postsurgical pain and stress. In the present
Selective retention of corticosterone by limbic structures in rat brain.
McEwen SB, et al.
Nature, 220(5170), 911-911 (1968)
Damiano Azzinnari et al.
Neuropharmacology, 85, 328-341 (2014-06-08)
In neuropsychiatry, animal studies demonstrating causal effects of environmental manipulations relevant to human aetiology on behaviours relevant to human psychopathologies are valuable. Such valid models can improve understanding of aetio-pathophysiology and preclinical discovery and development of new treatments. In depression
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