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C2755

Sigma-Aldrich

Cortisone

≥95%

Sinônimo(s):

17α,21-Dihydroxy-4-pregnene-3,11,20-trione, 17α-Hydroxy-11-dehydrocorticosterone, 4-Pregnene-17α,21-diol-3,11,20-trione, Kendall’s Compound E, Reichstein’s Substance Fa

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About This Item

Fórmula empírica (Notação de Hill):
C21H28O5
Número CAS:
53-06-5
Peso molecular:
360.44
Beilstein:
1356062
Número CE:
200-162-4
Número MDL:
MFCD00003610
Código UNSPSC:
51111800
ID de substância PubChem:
24278304
NACRES:
NA.77

fonte biológica

synthetic

Nível de qualidade

200

esterilidade

non-sterile

Ensaio

≥95%

Formulário

powder

técnica(s)

inhibition assay: suitable

pf

223-228 °C (dec.) (lit.)

solubilidade

chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

Condições de expedição

ambient

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)CC(=O)[C@H]23

InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

chave InChI

MFYSYFVPBJMHGN-ZPOLXVRWSA-N

Informações sobre genes

human ... SERPINA6(866)

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Aplicação

Cortisone has been used:
  • to validate a 1β-HSD1 (11β-hydroxysteroid dehydrogenase type 1) inhibitor
  • to study the sensitivity of erythropoietic and granulopoietic progenitor cells to cortisone
  • in the determination of rates of cortisol oxidation by 11βHSD

Ações bioquímicas/fisiológicas

Cortisone (11 dehydro 17 hydroxycortico-sterone) is an anti-inflammatory glucocorticoid that delays wound healing after surgeries. It postpones the healing process by affecting the appearance of inflammatory cells, ground substance, fibroblasts, collagen, regenerating capillaries, and epithelial migration. Glucocorticoids have anti-inflammatory, anti-allergic and immunosuppressive properties and are extensively used in treatment and therapy.
Cortisone is a glucocorticoid; a corticosterone analog that has approximately twice the anti-inflammatory potency as corticosterone but much lower Na2+ retention potency.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Warning

Frases de perigo

H361d

Classificações de perigo

Repr. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
BCCF2782
BCBZ8329
BCBT7908
BCBR1049V
BCBK3819V

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Anti-Cortisol Antibody, 3-CMO, clone F4P1A3 clone F4P1A3, Chemicon®, from mouse

Sigma-Aldrich

MAB1243

Anti-Cortisol Antibody, 3-CMO, clone F4P1A3

Aldosterone ≥95% (HPLC)

Sigma-Aldrich

A9477

Aldosterone

Corticosterone ≥92%

Sigma-Aldrich

C2505

Corticosterone

Hidrocortisona European Pharmacopoeia (EP) Reference Standard

Y0001092

Hidrocortisona

Hydrocortisone Impurity F Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2158

Hydrocortisone Impurity F

Cortisol-D4 (9,11,12, 12-D4) solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

C-113

Cortisol-D4 (9,11,12, 12-D4) solution

Prednisone ≥98%

Sigma-Aldrich

P6254

Prednisone

F Zalman et al.
The Journal of experimental medicine, 149(1), 67-72 (1979-01-01)
The sensitivity of erythropoietic (BFU-E) and granulopoietic (CFU-C) progenitor cells to dexamethasone and cortisone was studied in cultures of mouse bone marrow. Although the log dose-response relationships had a similar form, the BFU-E were much more sensitive than the CFU-C
Hengmiao Cheng et al.
Bioorganic & medicinal chemistry letters, 20(9), 2897-2902 (2010-04-07)
The design and development of a series of highly selective pyrrolidine carboxamide 11beta-HSD1 inhibitors are described. These compounds including PF-877423 demonstrated potent in vitro activity against both human and mouse 11beta-HSD1 enzymes. In an in vivo assay, PF-877423 inhibited the
Elif I Ikitimur-Armutak et al.
Microvascular research, 109, 26-33 (2016-10-30)
Anti-angiogenic activity of palladium (Pd)(II)-based complexes is unknown despite their quite powerful anticancer activity. This study was therefore carried out to evaluate both in vivo anti-angiogenic effect and in vitro cytotoxic activity of a Pd(II)-based complex. ([Pd(sac)(terpy)](sac)·4H2O(sac=saccharinate and terpy=2,2':6',2″-terpyridine)) on
B Edwin et al.
Surgical endoscopy, 15(6), 589-591 (2001-10-10)
[corrected] We set out to record the operative times of an experienced laparoscopic team and assess the feasibility of outpatient laparoscopic adrenalectomy when optimal anesthesia was also offered to all patients. The study included 13 patients with aldosterone/cortisone hypersecretion and/or
Rowan S Hardy et al.
Swiss medical weekly, 142, w13650-w13650 (2012-08-08)
The anti-inflammatory actions of therapeutic glucocorticoids are well established and these drugs are widely used to treat a variety of inflammatory conditions. It is also clear that endogenously synthesised glucocorticoids have an important role in regulating inflammatory responses. Traditionally, our
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