C2505

Corticosterone

≥92% (HPLC), powder, corticosteroid hormone

• Sinônimo(s): 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
• Fórmula empírica (Notação de Hill): C₂₁H₃₀O₄
• Número CAS: 50-22-6
• Peso molecular: 346.46
• Beilstein: 2339601
• Número CE: 200-019-6
• Número MDL: MFCD00037715
• Código UNSPSC: 51111800
• ID de substância PubChem: 24278302
• NACRES: NA.77

Propriedades

• Nome do produto: Corticosterone, ≥92%
• fonte biológica: synthetic (organic)
• Nível de qualidade: 200
• Ensaio: ≥92%
• Formulário: powder
• pf: 179-183 °C (lit.)
• solubilidade: chloroform: 50 mg/mL, clear, colorless to faintly yellow
• Condições de expedição: ambient
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• chave InChI: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• Informações sobre genes: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

Descrição

Aplicação

Corticosterone has been used:

• in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice
• as a stress inducing hormone in pregnant mice
• to test its effect on depression-related behaviors in mice

Ações bioquímicas/fisiológicas

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.

Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands. However, it may also be synthesized in non-adrenal tissues including leydig cells of testes and in murine thymus. Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress. It is produced by HPA activation in response to stress in myeloid cells. Elevated levels of corticosterone is observed in Huntington′s disease (HD).

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves