QBD10761

t-Boc-N-amido-dPEG^®₁₂-acid

>95% (HPLC)

• Sinônimo(s): t-Boc-N-amido-PEG₁₂-COOH, t-Boc-N-amido-PEG₁₂-acid, t-Boc-PEG-acid, BocNH-​PEG₁₂-​CH₂CH₂COOH
• Fórmula empírica (Notação de Hill): C₃₂H₆₃NO₆₁
• Peso molecular: 1437.81
• Número MDL: MFCD13185149
• Código UNSPSC: 12352106
• NACRES: NA.22

Propriedades

• Ensaio: >95% (HPLC)
• forma: solid or viscous liquid
• adequação da reação: reaction type: Pegylations
• arquitetura do polímero: shape: linear; functionality: heterobifunctional
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C

Descrição

Características e benefícios

t-Boc-N-amido-dPEG₁₂-acid is a monodisperse PEG product that is useful for peptide synthesis. The 40-atoms-long dPEG spacer allows the introduction of a medium-length, hydrophilic spacer onto either end of a peptide chain or on an amino acid side chain. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. The Boc protecting group removes easily with acids such as trifluoroacetic acid (TFA), HF, and trifluoromethane sulfonic acid (TFMSA). Peptide PEGylation imparts water solubility to hydrophobic peptide chains, expands the PEG-peptide conjugates′ hydrodynamic volumes (thus decreasing renal clearance), and protects PEGylated peptides from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the t-Boc-N-amido-dPEG_n-acid (n=4, 8, 12, 24, 36) product series.

Informações legais

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable