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D0387

Sigma-Aldrich

6,7-Dimethyl-5,6,7,8-tetrahydropterine hydrochloride

≥95%

Sinônimo(s):

2-Amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine, DMPH4

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About This Item

Fórmula empírica (Notação de Hill):
C8H13N5O · HCl
Número CAS:
945-43-7
Peso molecular:
231.68
Número MDL:
MFCD00012731
Código UNSPSC:
12352100
ID de substância PubChem:
57654058
NACRES:
NA.22

Nível de qualidade

100

Ensaio

≥95%

forma

powder

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Cl[H].CC1Nc2nc(N)nc(O)c2NC1C

InChI

1S/C8H13N5O.ClH/c1-3-4(2)11-6-5(10-3)7(14)13-8(9)12-6;/h3-4,10H,1-2H3,(H4,9,11,12,13,14);1H

chave InChI

GIHYTRGUZVYCQX-UHFFFAOYSA-N

Categorias relacionadas

Ações bioquímicas/fisiológicas

Synthetic reduced pterin cofactor for nitric oxide synthetase, and for phenylalanine, tyrosine, and tryptophan hydroxylases; less active than the natural cofactor, tetrahydrobiopterin (BH4).

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palavra indicadora

Danger

Frases de perigo

H315 - H318 - H335

Classificações de perigo

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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L-Tyrosine BioUltra, ≥99.0% (NT)

Sigma-Aldrich

93829

L-Tyrosine

4-Aminopyridine ≥99%

Sigma-Aldrich

275875

4-Aminopyridine

Sodium periodate ACS reagent, ≥99.8%

Sigma-Aldrich

311448

Sodium periodate

L-Tyrosine reagent grade, ≥98% (HPLC)

Sigma-Aldrich

T3754

L-Tyrosine

Reid M McCarty et al.
Biochemistry, 48(11), 2301-2303 (2009-02-24)
To elucidate the early steps required during biosynthesis of a broad class of 7-deazapurine-containing natural products, we have studied the reaction catalyzed by Escherichia coli QueD, a 6-pyruvoyl-5,6,7,8-tetrahydropterin synthase (PTPS) homologue possibly involved in queuosine biosynthesis. While mammalian PTPS homologues
R Chaube et al.
The Journal of endocrinology, 175(2), 329-342 (2002-11-14)
In Heteropneustes fossilis, ovariectomy inhibited in vivo brain (hypothalamus-pituitary, telencephalon and medulla oblongata) tyrosine hydroxylase (TH) activity with significant effects in weeks 2, 3, 4 and 5 of the gonadal resting phase and in weeks 3, 4 and 5 of
D Chen et al.
The Journal of biological chemistry, 273(40), 25594-25601 (1998-09-25)
A gene encoding phenylalanine hydroxylase has been cloned from Chromobacterium violaceum and expressed in Escherichia coli. The purified phenylalanine hydroxylase contains copper, which does not support enzymatic activity. Upon removal of copper by dithiothreitol (DTT), the enzyme contains substoichiometric amounts
S O Pember et al.
Biochemistry, 26(14), 4477-4483 (1987-07-14)
The interaction of pterin-dependent phenylalanine hydroxylase from Chromobacterium violaceum with the cofactor analogue 5-deaza-6-methyltetrahydropterin and the cofactor 6,7-dimethyltetrahydropterin (DMPH4) has been investigated by multifrequency electron spin resonance (ESR) spectroscopy. 5-Deaza-6-methyltetrahydropterin, which lacks the N-5 nitrogen present in the pyrazine ring
Dexamethasone and phenylalanine hydroxylase activities in rats.
G A Walsh et al.
Biochemical Society transactions, 18(2), 320-321 (1990-04-01)
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