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Documentos Principais

93829

Sigma-Aldrich

L-Tyrosine

≥99.0% (NT), suitable for ligand binding assays, BioUltra

Sinônimo(s):

(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid, 3-(4-Hydroxyphenyl)-L-alanine

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About This Item

Fórmula linear:
4-(HO)C6H4CH2CH(NH2)CO2H
Número CAS:
Peso molecular:
181.19
Beilstein:
392441
Número CE:
Número MDL:
Código UNSPSC:
12352209
eCl@ss:
32160406
ID de substância PubChem:
NACRES:
NA.26

Nome do produto

L-Tyrosine, BioUltra, ≥99.0% (NT)

linha de produto

BioUltra

Nível de qualidade

Ensaio

≥99.0% (NT)

Formulário

powder or crystals

atividade óptica

[α]20/D −11.5±1.0°, c = 4% in 1 M HCl

técnica(s)

ligand binding assay: suitable

Impurezas

insoluble matter, passes filter test
≤0.5% foreign amino acids

resíduo de ignição

≤0.1%

perda

≤0.2% loss on drying, 20 °C (HV)

cor

white

pf

>300 °C (dec.) (lit.)

solubilidade

1 M HCl: 25 mg/mL, clear, colorless (hot)

traços de ânion

chloride (Cl-): ≤400 mg/kg
sulfate (SO42-): ≤300 mg/kg

traços de cátion

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
NH4+: ≤200 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

Absorção

cut-off at 310 nm in 1 M HCl at 0.5 M

cadeia de caracteres SMILES

N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

chave InChI

OUYCCCASQSFEME-QMMMGPOBSA-N

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Aplicação

L-Tyrosine was used in tyrosine hydroxylase (TH) enzyme activity assay. It was also used as a substrate for tyrosinase enzyme in the growth media of Vibrio cholerae strains to stimulate melanin formation. It may be used as a precursor in the synthesis of (-)-MY 336a. MY 336a, a β-adrenergic receptor antagonist, was initially isolated from the culture broth of Streptomyces gabonae KY2234 (ATCC 15282). It may be used in the synthesis of 3-bromo-L-tyrosine and 3,5-dibromo-L-tyrosine.

Outras notas

Amino acid precursor of dopamine and other catecholamines
Growth requirements of various microorganisms

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves


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Sigma-Aldrich

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L-leucina

V E Coyne et al.
Applied and environmental microbiology, 58(9), 2861-2865 (1992-09-01)
Vibrio cholerae synthesized the pigment melanin in response to specific physiological conditions that were stressful to the bacterium. Pigmentation was induced when V. cholerae was subjected to hyperosmotic stress in conjunction with elevated growth temperatures (above 30 degrees C). The
CRC Handbook of Microbiology, 4, 1-1 (1974)
Robert S Phillips et al.
Amino acids, 44(2), 529-532 (2012-07-28)
L-Tyrosine is converted to 3-bromo-L-tyrosine in good yield by reaction with 1.2 equiv. of DMSO in HBr/AcOH, while reaction with 2.2 equiv. of DMSO under comparable conditions results in formation of 3,5-dibromo-L-tyrosine in good yield. This is the simplest, safest
Andisheh Eslamboli et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(4), 769-777 (2005-01-28)
The therapeutic potential of glial cell line-derived neurotrophic factor (GDNF) for Parkinson's disease is likely to depend on sustained delivery of the appropriate amount to the target areas. Recombinant adeno-associated viral vectors (rAAVs) expressing GDNF may be a suitable delivery
Total Synthesis of (-)-MY 336a from L-Tyrosine.
Liao XW, et al.
Journal of Heterocyclic Chemistry, 47(1), 50-53 (2010)

Artigos

Inborn errors of metabolism are caused by changes in specific enzymatic reactions and hundreds of different such alterations, which affect about 1 of every 5000 newborns, have been characterized.

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