924075

NHS ester-a-TCO

• Sinônimo(s): (E)-N-Hydroxysuccinyl 2-(1-ax-hydroxycyclooct-4-en-1-yl)acetate, 2,5-Dioxopyrrolidin-1-yl (R,E)-2-(1-hydroxycyclooct-4-en-1-yl)acetate, Amine-reactive axial 5-hydroxy-trans-cyclooctene
• Fórmula empírica (Notação de Hill): C₁₄H₁₉NO₅
• Peso molecular: 281.30
• Código UNSPSC: 12352108
• NACRES: NA.22

Propriedades

• adequação da reação: reaction type: click chemistry; reactivity: amine reactive; reagent type: chemical modification reagent; reagent type: cross-linking reagent
• Nível de qualidade: 100
• grupo funcional: NHS ester
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O[C@@]1(CC(ON2C(CCC2=O)=O)=O)CC/C=C/CCC1

Descrição

Aplicação

NHS ester-a-TCO is an axial trans-cyclooctene (a-TCO) for bioconjugation and protein labeling. NHS ester-a-TCO has an amine-reactive NHS ester, and the a-TCO reacts rapidly with tetrazines through Diels–Alder reactions, a type of bioorthogonal, copper-free click chemistry. As demonstrated by the Joe Fox lab in Pigga, et al, a-TCOs are more reactive and hydrophilic than standard TCOs, providing favorable physiochemical properties for live-cell and in vivo labeling.

Other new a-TCOs:

• TAMRA-a-TCO (924083)
• Alkyne-a-TCO (924091)
• Amine-a-TCO (924113)

Outras notas

General, Divergent Platform for Diastereoselective Synthesis of trans-Cyclooctenes with High Reactivity and Favorable Physiochemical Properties

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable