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608033

Sigma-Aldrich

L-Arginine-13C6,15N4 hydrochloride

99 atom % 13C, 99 atom % 15N, 95% (CP)

Sinônimo(s):

SILAC Amino Acid, (S)-(+)-2-Amino-5-[(aminomethyl)amino]pentanoic acid-13C6,15N4 hydrochlordie, 13C and 15N Labeled ARG, 13C and 15N Labeled arginine hydrochloride

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About This Item

Fórmula linear:
H215N13C(15NH)15NH(13CH2)313CH(15NH2)13CO2H · HCl
Número CAS:
202468-25-5
Peso molecular:
220.59
Número MDL:
MFCD04118221
Código UNSPSC:
12352209
ID de substância PubChem:
329759227
NACRES:
NA.12

pureza isotópica

99 atom % 13C
99 atom % 15N

Nível de qualidade

200

Ensaio

95% (CP)

forma

solid

atividade óptica

[α]20/D +22°, c = 12 in 10% HCl

composição

L-isomer, 97%

técnica(s)

bio NMR: suitable
protein expression: suitable

pf

226-230 °C (dec.) (lit.)

alteração de massa

M+10

cadeia de caracteres SMILES

Cl.[15NH2][13C@@H]([13CH2][13CH2][13CH2][15NH][13C]([15NH2])=[15NH])[13C](O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1,9+1,10+1;

chave InChI

KWTQSFXGGICVPE-YAUSPDTOSA-N

Categorias relacionadas

Aplicação

Pulsed Stable Isotope labeling of amino acid has been used to study host-cell function, survival, the precise intracellular pathways in protein synthesis of HIV-1 infected human monocytederived macrophages.

Embalagem

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
MBBD2791
MBBC5181
MBBC4710
MBBC4371
MBBC3108

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Alex A Makarov et al.
Nature communications, 10(1), 3056-3056 (2019-07-13)
Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and mechanics and mutated in a wide range of human diseases. Yet little is known about the molecular architecture of lamins and mechanisms of their assembly. Here we
Roberto Ravasio et al.
Science advances, 6(15), eaax2746-eaax2746 (2020-04-15)
The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for the clinical use of LSD1 inhibitors. In acute promyelocytic leukemia (APL), pharmacological doses of retinoic acid (RA) induce differentiation of APL cells, triggering degradation of
Thaís L S Araujo et al.
Cell stress & chaperones, 24(1), 273-282 (2019-01-16)
Heat shock protein-70 (HSP70) is crucial for proteostasis and displays cell-protective effects. Meanwhile, enhanced levels of cell-surface (cs) and secreted HSP70 paradoxically associate with pathologic cardiovascular conditions. However, mechanisms regulating csHSP70 pool are unknown. We hypothesized that total and csHSP70
Stephanie D Kraft-Terry et al.
Journal of proteome research, 10(6), 2852-2862 (2011-04-20)
Dynamic interactions between human immunodeficiency virus-1 (HIV-1) and the macrophage govern the tempo of viral dissemination and replication in its human host. HIV-1 affects macrophage phenotype, and the macrophage, in turn, can modulate the viral life cycle. While these processes
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Developmental cell, 49(3), 393-408 (2019-04-16)
The NAD+-dependent deacetylase Sirtuin 1 (SIRT1) is down-regulated in triple-negative breast cancer. To determine the mechanistic basis by which reduced SIRT1 expression influences processes related to certain aggressive cancers, we examined the consequences of depleting breast cancer cells of SIRT1.
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Conteúdo relacionado

Protein Structural Analysis

Protein structure provides valuable information that can be used to infer protein function. The study of protein structure and mapping of protein interactions, expression levels, and location enables the identification of disease biomarkers and potential drug targets for therapeutic treatment.

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