411361

Diethyl (bromodifluoromethyl)phosphonate

96%

• Sinônimo(s): (Bromodifluoromethyl)phosphonic acid diethyl ester
• Fórmula linear: BrCF₂P(O)(OC₂H₅)₂
• Número CAS: 65094-22-6
• Peso molecular: 267.01
• Número MDL: MFCD00069118
• Código UNSPSC: 12352108
• ID de substância PubChem: 24865745
• NACRES: NA.22

Propriedades

• Ensaio: 96%
• Formulário: liquid
• adequação da reação: reaction type: C-C Bond Formation
• índice de refração: n20/D 1.417 (lit.)
• p.e.: 40-41 °C/0.05 mmHg (lit.)
• densidade: 1.503 g/mL at 25 °C (lit.)
• grupo funcional: bromo; fluoro; phosphonate
• cadeia de caracteres SMILES: CCOP(=O)(OCC)C(F)(F)Br
• InChI: 1S/C5H10BrF2O3P/c1-3-10-12(9,11-4-2)5(6,7)8/h3-4H2,1-2H3
• chave InChI: QRADKVYIJIAENZ-UHFFFAOYSA-N

Descrição

Aplicação

Reactant for:

• Preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3)
• Synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps
• P-C bond cleavage on basic hydrolysis
• Preparation of a prodrug for intracellular delivery of protein tyrosine phosphatase 1B (PTP1B) inhibitor (nonhydrolyzable difluoromethylphosphonate moiety)

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves