302309

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

Cl 13.5-15.5 %

• Sinônimo(s): Chloro(diisopropylamino)-β-cyanoethoxyphosphine
• Fórmula linear: [(CH₃)₂CH]₂NP(Cl)OCH₂CH₂CN
• Número CAS: 89992-70-1
• Peso molecular: 236.68
• Beilstein: 3588525
• Número MDL: MFCD00011544
• Código UNSPSC: 12352100
• ID de substância PubChem: 24858245
• NACRES: NA.22

Propriedades

• Formulário: liquid
• composição: Cl, 13.5-15.5%
• índice de refração: n/D 1.476-1.480
• p.e.: 103 -105 °C/0.1 hPa
• densidade: 1.061 g/mL at 25 °C (lit.)
• grupo funcional: amine; nitrile
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CC(C)N(C(C)C)P(Cl)OCCC#N
• InChI: 1S/C9H18ClN2OP/c1-8(2)12(9(3)4)14(10)13-7-5-6-11/h8-9H,5,7H2,1-4H3
• chave InChI: QWTBDIBOOIAZEF-UHFFFAOYSA-N

Descrição

Aplicação

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite was employed:

• for selective monophosphorylation of carbohydrates and nucleosides
• for conversion of protected ribonucleosides to phosphoramidites
• as phosphitylating reagent for 3′-hydroxyl groups in the synthesis of oligodeoxyribonucleotides
• in a scalable, solution-phase oligonucleotide synthesis employing phosphoramidite chemistry and DMT-, iBu- and Bz-protected monomers. Intermediates were isolated by extraction without further purification

Informações de segurança

• Pictogramas: GHS02,GHS05
• Palavra indicadora: Danger
• Frases de perigo: H250,H314
• Declarações de precaução: P210 - P231 + P232 - P280 - P303 + P361 + P353 - P305 + P351 + P338 - P370 + P378
• Classificações de perigo: Eye Dam. 1 - Pyr. Liq. 1 - Skin Corr. 1B
• Código de classe de armazenamento: 4.2 - Pyrophoric and self-heating hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): 230.0 °F - closed cup
• Ponto de fulgor (°C): 110 °C - closed cup
• Equipamento de proteção individual: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter