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281255

Sigma-Aldrich

1,4-Dihydroxy-2-naphthoic acid

97%

Sinônimo(s):

1,4-Dihydroxy-2-carboxy naphthoic acid, 1,4-Dihydroxy-2-naphthalenecarboxylic acid, 1,4-Dihydroxy-2-naphthoate

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About This Item

Fórmula linear:
(HO)2C10H5CO2H
Número CAS:
31519-22-9
Peso molecular:
204.18
Número CE:
250-674-7
Número MDL:
MFCD00010370
Código UNSPSC:
12352100
ID de substância PubChem:
24856853
NACRES:
NA.22

Nível de qualidade

100

Ensaio

97%

pf

220 °C (dec.) (lit.)

grupo funcional

carboxylic acid

cadeia de caracteres SMILES

OC(=O)c1cc(O)c2ccccc2c1O

InChI

1S/C11H8O4/c12-9-5-8(11(14)15)10(13)7-4-2-1-3-6(7)9/h1-5,12-13H,(H,14,15)

chave InChI

VOJUXHHACRXLTD-UHFFFAOYSA-N

Categorias relacionadas

Descrição geral

1,4-Dihydroxy-2-naphthoic acid from Propionibacterium freudenreichii is known to promote the proliferation of Bifidobacterium. It has potential therapeutic application for psoriasis treatment.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
STBF3225V
STBC4215V
STBC2929V
MKBD8659
STBB5204

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1-Naphthoic acid 96%

Sigma-Aldrich

N1909

1-Naphthoic acid

5-Hydroxy-1,4-naphthoquinone 97%

Sigma-Aldrich

H47003

5-Hydroxy-1,4-naphthoquinone

Anthraquinone 97%

Sigma-Aldrich

A90004

Anthraquinone

2-Aminothiophenol 99%

Sigma-Aldrich

274240

2-Aminothiophenol

Menadione crystalline

Sigma-Aldrich

M5625

Menadione

D J Shaw et al.
Journal of bacteriology, 152(3), 1132-1137 (1982-12-01)
Four independent menaquinone (vitamin K(2))-deficient mutants of Escherichia coli, blocked in the conversion of o-succinylbenzoate (OSB) to 1,4-dihydroxy-2-naphthoate (DHNA), were found to represent two distinct classes. Enzymatic complementation was observed when a cell-free extract of one mutant was mixed with
M Matsubara et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 21(8), 1437-1447 (2009-10-09)
The main component of the metabolic by-products of fermentation by Propionibacterium freudenreichii ET-3 is 1,4-dihydroxy-2-naphthoic acid (DHNA), which has a naphthoquinone skeleton, as in vitamin K2. This study showed that DHNA improved bone mass reduction with osteoporosis model mice caused
Alexey P Kostikov et al.
The Journal of organic chemistry, 72(24), 9190-9194 (2007-10-26)
Irradiation of alcohols, phenols, and carboxylic acids "caged" with the 2,5-dihydroxybenzyl group or its naphthalene analogue results in the efficient release of the substrate. The initial byproduct of the photoreaction, 4-hydroxyquinone-2-methide, undergoes rapid tautomerization into methyl p-quinone. The UV spectrum
K Suvarna et al.
Journal of bacteriology, 180(10), 2782-2787 (1998-06-06)
A key reaction in the biosynthesis of menaquinone involves the conversion of the soluble bicyclic naphthalenoid compound 1, 4-dihydroxy-2-naphthoic acid (DHNA) to the membrane-bound demethylmenaquinone. The enzyme catalyzing this reaction, DHNA-octaprenyltransferase, attaches a 40-carbon side chain to DHNA. The menA
Junichi Sakai et al.
Bioorganic & medicinal chemistry, 16(9), 4854-4859 (2008-04-05)
Ac-DNLD-CHO is a novel caspase-3 specific peptide inhibitor that was rationally designed by our computational strategy. The specificity was shown to be due to the specific interaction of NLD moiety with the active site of caspase-3 on the basis of
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