P8293

Protoporphyrin IX

≥95%

• Sinônimo(s): 3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid, Kammerer’s porphyrin, Ooporphyrin
• Fórmula empírica (Notação de Hill): C₃₄H₃₄N₄O₄
• Número CAS: 553-12-8
• Peso molecular: 562.66
• Beilstein: 380795
• Número CE: 209-033-7
• Número MDL: MFCD00151109
• Código UNSPSC: 41106305
• ID de substância PubChem: 24278655
• NACRES: NA.32

Propriedades

• Ensaio: ≥95%
• forma: powder
• fluorescência: λ_ex 402 nm; λ_em 625 nm (bound to HRP); λ_ex 409 nm; λ_em 633 nm
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cc1c(CCC(O)=O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(O)=O
• InChI: 1S/C34H34N4O4/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25/h7-8,13-16,35,38H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42)/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-
• chave InChI: KSFOVUSSGSKXFI-UJJXFSCMSA-N

Descrição

Descrição geral

Protoporphyrin IX belongs to the porphyrin family, which are a class of tetrapyrroles. It is the iron-free form of hemin and amphiphilic in nature. It is the precursor of heme in its biosynthetic pathway.

Protoporphyrin IX imparts red color to heme and is the major porphyrin in blood. It is synthesized from protoporphyrinogen IX in the presence of protoporphyrinogen IX oxidase.

Aplicação

Protoporphyrin IX has been used:

• as a standard in protoporphyrin assays
• in fluorescence spectra analysis
• to treat cells in cell culture to study heme-mediated ferroportin 1 transcription

Activates soluble guanylyl cyclase.

Ações bioquímicas/fisiológicas

Protoporphyrin IX penetrates human erythrocytes and aids the release of oxygen from them. It forms complexes with myoglobin and hemoglobin. It is a photosensitizer used in the photodynamic therapy of cancer.

Protoporphyrin IX levels are elevated in tumor cells due to metabolism anomalies compared to normal cells.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves