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248924

Sigma-Aldrich

7-Amino-4-(trifluoromethyl)coumarin

≥99%

Sinônimo(s):

Coumarin 151

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About This Item

Fórmula empírica (Notação de Hill):
C10H6F3NO2
Número CAS:
53518-15-3
Peso molecular:
229.16
Beilstein:
4456797
Número CE:
258-599-1
Número MDL:
MFCD00006858
Código UNSPSC:
12171500
ID de substância PubChem:
24854960
NACRES:
NA.47

Nível de qualidade

100

Ensaio

≥99%

forma

(Powder or Crystals or Chunks)

pf

221-222 °C (lit.)

λmax

≤207 nm

aplicação(ões)

diagnostic assay manufacturing
hematology
histology

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

Nc1ccc2c(OC(=O)C=C2C(F)(F)F)c1

InChI

1S/C10H6F3NO2/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4H,14H2

chave InChI

JBNOVHJXQSHGRL-UHFFFAOYSA-N

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Descrição geral

7-Amino-4-(trifluoromethyl)coumarin (AFC) is a novel fluorescent marker used for the detection of proteinases.

Aplicação

Suitable as laser dye

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
MKCP6310
MKCL5880
MKCH9609
MKCF1142
MKCC0606

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Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

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S W Cox et al.
Journal of periodontal research, 25(3), 164-171 (1990-05-01)
Substrate impregnated paper discs were prepared using peptidyl derivatives of 7-amino-4-trifluoromethylcoumarin (AFC). After incubation with test solutions, the green, UV-induced fluorescence of AFC liberated by enzyme activity was distinguishable from the blue-violet fluorescence of the substrates. The AFC could then
Mohammad Javad Chaichi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 59(6), 1145-1150 (2003-03-28)
The chemiluminescence characteristics of seven different cumarin derivatives were studied in detail. The fluorescence and chemiluminescence spectra were compared; all cumarins used were found to act as blue fluorescers. The intensity and kinetic parameters for the chemiluminescent systems were evaluated
E D Pederson et al.
Journal of clinical periodontology, 21(8), 519-525 (1994-09-01)
Treponema denticola (Td) and Porphyromonas gingivalis (Pg) are associated with human moderate and severe adult periodontal diseases. This study quantifies these two anaerobes and their trypsin-like (TL) activities in subgingival plaque collected from both clinically healthy and periodontally diseased sites
Synthesis and chemistry of 7-amino-4-(trifluoromethyl)coumarin and its amino acid and peptide derivatives
Bissell E R
The Journal of Organic Chemistry, 45, 2283?2287-2283?2287 (1980)
S W Cox et al.
Archives of oral biology, 32(9), 599-605 (1987-01-01)
The cysteine proteinases cathepsins B and L have collagenolytic potential and so have been implicated in connective-tissue breakdown in chronic periodontitis. Synthetic peptide substrates are often used to detect proteolytic enzymes. The action of homogenates of inflamed gingiva tissue against
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