144436
Isobutyramide
99%
Sinônimo(s):
2-Methylpropionamide
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About This Item
Fórmula linear:
(CH3)2CHCONH2
Número CAS:
Peso molecular:
87.12
Número CE:
Número MDL:
Código UNSPSC:
12352100
ID de substância PubChem:
NACRES:
NA.22
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Nível de qualidade
Ensaio
99%
Formulário
solid
p.e.
216-220 °C (lit.)
pf
127-131 °C (lit.)
densidade
1.013 g/mL at 25 °C (lit.)
grupo funcional
amide
cadeia de caracteres SMILES
CC(C)C(N)=O
InChI
1S/C4H9NO/c1-3(2)4(5)6/h3H,1-2H3,(H2,5,6)
chave InChI
WFKAJVHLWXSISD-UHFFFAOYSA-N
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Aplicação
Isobutyramide was used for chemical grafting of human serum albumin during the synthesis of sequentialy assembled protein capsules.
Ações bioquímicas/fisiológicas
Isobutyramide activates transcription of human gamma-globin gene and murine embryonic epsilon(y)-globin gene. It is useful in the treatment of β-thalassemia and sickle cell disease.
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J Zhang et al.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 16(4), 187-193 (2003-08-09)
To examine the effect of isobutyramide synthesized in our laboratory on human and murine globin gene expression and to test cell toxicity of the drug. MEL cells were transfected with the recombinant construct muLCRAgammapsibetadeltabeta and the stable transformants were cultured
S P Perrine et al.
The American journal of pediatric hematology/oncology, 16(1), 67-71 (1994-02-01)
Stimulating expression of the normal fetal globin genes is a preferred method of ameliorating sickle cell disease and beta-thalassemia for the majority of patients in North America who do not have appropriate bone marrow donors. Due to increased survival of
G B Strambini et al.
Biochemistry, 29(1), 203-208 (1990-01-09)
The phosphorescence properties of liver alcohol dehydrogenase from horse were characterized at limiting concentrations of coenzyme and coenzyme analogues. The emission decay kinetics of Trp-314 in strong, slowly exchanging, ternary complexes with NADH/isobutyramide, NAD/pyrazole, and NADH/dimethyl sulfoxide displays a markedly
M D Cappellini et al.
Annals of the New York Academy of Sciences, 850, 110-119 (1998-07-21)
The aims of this study were to ascertain tolerability, safety and efficacy of oral isobutyramide (150 mg/kg bw/day) in stimulating fetal hemoglobin production in twelve thalassemia intermedia patients. Patients were treated for 28 days and followed for a further 28
Thermosensitive molecular assemblies from poly(amidoamine) dendron-based lipids.
Kenji Kono et al.
Angewandte Chemie (International ed. in English), 50(28), 6332-6336 (2011-05-21)
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