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Antitumor activity of sorafenib-incorporated nanoparticles of dextran/poly(dl-lactide-co-glycolide) block copolymer.

Nanoscale research letters (2012-01-31)
Do Hyung Kim, Min-Dae Kim, Cheol-Woong Choi, Chung-Wook Chung, Seung Hee Ha, Cy Hyun Kim, Yong-Ho Shim, Young-Il Jeong, Dae Hwan Kang
ABSTRACT

Sorafenib-incoporated nanoparticles were prepared using a block copolymer that is composed of dextran and poly(DL-lactide-co-glycolide) [DexbLG] for antitumor drug delivery. Sorafenib-incorporated nanoparticles were prepared by a nanoprecipitation-dialysis method. Sorafenib-incorporated DexbLG nanoparticles were uniformly distributed in an aqueous solution regardless of the content of sorafenib. Transmission electron microscopy of the sorafenib-incorporated DexbLG nanoparticles revealed a spherical shape with a diameter < 300 nm. Sorafenib-incorporated DexbLG nanoparticles at a polymer/drug weight ratio of 40:5 showed a relatively uniform size and morphology. Higher initial drug feeding was associated with increased drug content in nanoparticles and in nanoparticle size. A drug release study revealed a decreased drug release rate with increasing drug content. In an in vitro anti-proliferation assay using human cholangiocarcinoma cells, sorafenib-incorporated DexbLG nanoparticles showed a similar antitumor activity as sorafenib. Sorafenib-incorporated DexbLG nanoparticles are promising candidates as vehicles for antitumor drug targeting.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 48,000-90,000
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Dextran from Leuconostoc mesenteroides, average mol wt 9,000-11,000
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Dextran from Leuconostoc mesenteroides, average mol wt 150,000
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Dextran from Leuconostoc mesenteroides, average mol wt 15,000-30,000
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Dextran from Leuconostoc mesenteroides, average mol wt 1,500,000-2,800,000
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Dextran from Leuconostoc mesenteroides, average mol wt 35,000-45,000
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Dextran from Leuconostoc spp., Mr ~40,000
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Dextran from Leuconostoc spp., Mr ~6,000
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Dextran from Leuconostoc spp., Mr ~70,000
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Dextran from Leuconostoc spp., Mr 450,000-650,000
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Dextran, enzymatic synth.
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Dextran from Leuconostoc mesenteroides, Mr ~60,000
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Dextran from Leuconostoc mesenteroides, Mr ~200,000
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Dextran from Leuconostoc spp., Mr ~100,000
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Dextran from Leuconostoc spp., Mr ~70000