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D4626

Sigma-Aldrich

Dextran from Leuconostoc mesenteroides

average mol wt 15,000-30,000

Linear Formula:
(C6H10O5)n
CAS Number:
EC Number:
MDL number:
NACRES:
NA.25

Quality Level

biological source

bacterial (Leuconostoc mesenteroides)

form

powder

optical activity

[α]/D 199°

mol wt

average mol wt 15,000-30,000

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General description

Dextran is a branched glucan composed of linear α(1→6) linked glucose units and α (1→3) link initiated branches. Dextran ranges in size from 10,000 to 150,000 kDa.

Application

Dextrans are used in many applications as volume extenders, osmotic pressure regulators, stabilizers, matrix components, copolymers, microcarriers, binding agents, viscosity modifiers, antithrombotics, lubricants and physical structure components. Dextrans may be used as long hydrophilic spacer arms to improve the performance (freedom of movement) of conjugated/bound proteins. Dextrans may be derivatized for use in biosensor systems. Dextrans of less than 60,000 kDa are generally considered low molecular weight dextrans. Low molecular weight dextrans are often preferred versus high molecular weight dextrans due to their viscosities, aggregation and permeation properties. High molecular weight, water-soluble, dextran polymers have been used in a wide variety of biomedical applications. Dextran (15,000-30,000), a low molecular weight dextran, may be used to study processes such as transient plasma membrane permeabilization. Dextran (15,000-30,000), may be used as a sugar based crowding agent in protein packing and folding studies.
Use of dextrans as long and hydrophilic spacer arms improves the performance of immobilized proteins acting on macromolecules.

Packaging

1 kg in poly drum

Preparation Note

With the exception of the highest MW dextran, D5501 (MW range = 5 million to 40 million), dextrans are very water soluble. Sigma tests the solubility of dextrans at concentrations generally exceeding 30 mg/ml in water. Dextrans are also freely soluble in DMSO, formamide, ethylene glycol, and glycerol. Neutral-aqueous dextran solutions can be sterilized by autoclaving at 110-115oC for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. The terminal reducing end group of dextran can be oxidized in alkaline solutions.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

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