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B3501

Sigma-Aldrich

Betaine hydrochloride

≥99%

Synonym(s):

(Carboxymethyl)trimethylammonium hydrochloride

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About This Item

Linear Formula:
(CH3)3N+CH2COOH · Cl-
CAS Number:
590-46-5
Molecular Weight:
153.61
Beilstein/REAXYS Number:
3916181
EC Number:
209-683-1
MDL number:
MFCD00011903
UNSPSC Code:
12352202
PubChem Substance ID:
24278266
NACRES:
NA.77

biological source

synthetic (organic)

assay

≥99%

form

powder or crystals

mp

241-242 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

[Cl-].C[N+](C)(C)CC(O)=O

InChI

1S/C5H11NO2.ClH/c1-6(2,3)4-5(7)8;/h4H2,1-3H3;1H

InChI key

HOPSCVCBEOCPJZ-UHFFFAOYSA-N

Gene Information

human ... BHMT(635) , BHMT2(23743)

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General description

Betaine (trimethyl glycine) is an osmoprotectant, which is highly effective than proline. It is formed in from choline. Betaine is usually present in grains, spinach, beets, broccoli, shellfish and marine algae.

Application

Betaine hydrochloride has been used as a component of fixative in HEPES or cacodylate buffer to improve preservation of the ultrastructural morphology of human spermatozoa.

Biochem/physiol Actions

Betaine hydrochloride can decrease hepatotoxicity, that is stimulated by ethanol.
End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Can Phytochemicals be Effective in Preventing Ethanol-Induced Hepatotoxicity in the Geriatric Population? An Evidence-Based Revisit
Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults, 163-170 (2015)
Improved preservation of ultrastructural morphology in human spermatozoa using betaine in the primary fixative
Swan MA
International Journal of Andrology, 20(1), 45- 54 (1997)
Effect of drying medium on the viability of dried
Selmer OE, et al.
Immobilized Cells: Basics and Applications, 11, 229-229 (1996)
Noha H Youssef et al.
The ISME journal, 8(3), 636-649 (2013-09-21)
We investigated the mechanisms of osmoadaptation in the order Halobacteriales, with special emphasis on Haladaptatus paucihalophilus, known for its ability to survive in low salinities. H. paucihalophilus genome contained genes for trehalose synthesis (trehalose-6-phosphate synthase/trehalose-6-phosphatase (OtsAB pathway) and trehalose glycosyl-transferring
Jun Cao et al.
Journal of biomedical nanotechnology, 9(11), 1847-1861 (2013-09-26)
pH-sensitive micelles are considered promising carriers for tumor targeted drug delivery. In this study, novel pH-sensitive star-shape copolymers of amphiphilic poly(epsilon-caprolactone)-b-poly(N, N-diethylaminoethyl methacrylate)-r-poly(N-(3-sulfopropyl)-N-methacryloxyethy-N, N-diethylammoniumbetaine) (4sPCLDEAS) are designed and synthesized with the combination of ring opening polymerization (ROP) and atom radical
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