C7017

Choline chloride

≥99%

• Synonym(s): (2-Hydroxyethyl)trimethylammonium chloride
• Linear Formula: (CH₃)₃N(Cl)CH₂CH₂OH
• CAS Number: 67-48-1
• Molecular Weight: 139.62
• Beilstein: 3563126
• EC Number: 200-655-4
• MDL number: MFCD00011721
• PubChem Substance ID: 57654039
• NACRES: NA.25

Properties

• biological source: synthetic
• Quality Level: 200
• Assay: ≥99%
• form: powder
• color: white
• mp: 302-305 °C (dec.) (lit.)
• SMILES string: [Cl-].C[N+](C)(C)CCO
• InChI: 1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1
• InChI key: SGMZJAMFUVOLNK-UHFFFAOYSA-M

Description

General description

Choline is a constituent of sphingomyelin and lecithin. It is a precursor of acetylcholine. Choline plays a vital role in methyl group metabolism, carcinogenesis and lipid transport. Choline deficiency is associated with fatty liver. It maintains cell structural integrity and cell signalling. Choline is implicated in the synthesis of phospholipids. It acts as a potent biomarker for ischemic heart disease.

Application

Choline chloride has been used:

• in choline release assay
• as an endogenous agonist of sigma-1 receptors (Sig-1Rs)
• as a standard to analyse interrelationships between methionine and choline metabolism

Biochem/physiol Actions

Choline is an essential nutrient, commonly grouped with the B complex vitamins, that plays key roles in many biological processes.

The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

Substrates

Choline acetyltransferase substrate

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves