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C7017

Sigma-Aldrich

Choline chloride

≥99%

Synonym(s):
(2-Hydroxyethyl)trimethylammonium chloride
Linear Formula:
(CH3)3N(Cl)CH2CH2OH
CAS Number:
Molecular Weight:
139.62
Beilstein:
3563126
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

biological source

synthetic

Quality Level

assay

≥99%

form

powder

color

white

mp

302-305 °C (dec.) (lit.)

SMILES string

[Cl-].C[N+](C)(C)CCO

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

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General description

Choline is a constituent of sphingomyelin and lecithin. It is a precursor of acetylcholine. Choline plays a vital role in methyl group metabolism, carcinogenesis and lipid transport. Choline deficiency is associated with fatty liver.[92] It maintains cell structural integrity and cell signalling.[93] Choline is implicated in the synthesis of phospholipids. It acts as a potent biomarker for ischemic heart disease.[94]

Application

Choline chloride has been used:
  • in choline release assay
[95]
  • as an endogenous agonist of sigma-1 receptors (Sig-1Rs)
  • [96]
  • as a standard to analyse interrelationships between methionine and choline metabolism
  • [97]

    Packaging

    10 mg in autosample vial
    5, 25, 100 g in glass bottle

    Biochem/physiol Actions

    Choline is an essential nutrient, commonly grouped with the B complex vitamins, that plays key roles in many biological processes.
    The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

    Substrates

    Choline acetyltransferase substrate

    Storage Class Code

    13 - Non Combustible Solids

    WGK

    WGK 1

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves

    Certificate of Analysis

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    Certificate of Origin

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