David R Maguire et al.
The Journal of pharmacology and experimental therapeutics, 345(3), 354-362 (2013-03-29)
Cannabinoid receptor agonists enhance the antinociceptive effects of μ-opioid receptor agonists, which suggests that combinations of these drugs might enhance therapeutic effectiveness (e.g., analgesia). However, it is not clear whether combinations of these drugs also enhance abuse or dependence liability....
Stefan W Toennes et al.
Journal of analytical toxicology, 37(3), 152-158 (2013-02-23)
Oral fluid (OF) tests aid in identifying drivers under the influence of drugs. In this study, 17 heavy cannabis users consumed alcohol to achieve steady blood alcohol concentrations of 0 to 0.7 g/L and smoked cannabis 3 h afterward. OF...
Going to pot.
Scientific American, 308(6), 34-34 (2013-06-05)
J M Jansma et al.
Translational psychiatry, 3, e234-e234 (2013-02-28)
Recent evidence has implicated the endocannabinoid (eCB) system in nicotine addiction. The eCB system also has an important role in reward mechanisms, and nicotine addiction has been associated with aberrant reward processing. Motivated by this evidence, we tested the hypothesis...
Z K Krowicki
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 63(6), 581-588 (2013-02-08)
We previously reported that delta-9-tetrahydrocannabinol (delta-9-THC), the primary psychoactive constituent of Cannabis sativa, inhibited gastric motor activity and evoked bradycardia and hypotension upon its parenteral administration in the rat. As prostanoids are important mediators of the actions of cannabinoids, we...