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Key Documents

8.04518

Sigma-Aldrich

N-Hydroxysuccinimide

≥99.0% (acidimetric), for peptide synthesis

Synonym(s):

N-Hydroxysuccinimide, 1-Hydroxy-2,5-pyrrolidinedione

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About This Item

Empirical Formula (Hill Notation):
C4H5NO3
CAS Number:
Molecular Weight:
115.09
MDL number:
UNSPSC Code:
12352115
EC Index Number:
228-001-3
NACRES:
NA.22

product name

N-Hydroxysuccinimide, for synthesis

Quality Level

assay

≥99.0% (acidimetric)

form

crystals

reaction suitability

reaction type: Addition Reactions

pH

5-7 (20 °C, 50 g/L in H2O)

mp

93-100 °C

application(s)

peptide synthesis

InChI

1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2

InChI key

NQTADLQHYWFPDB-UHFFFAOYSA-N

Application

  • Direct Cα-heteroarylation of structurally diverse ethers: This study showcases a mild N-hydroxysuccinimide mediated cross-dehydrogenative coupling reaction, expanding the utility of NHS in organic synthesis. (Liu et al., 2017).

Analysis Note

Assay (acidimetric): ≥ 99.0 %
Melting range (lower value): ≥ 95 °C
Melting range (upper value): ≤ 100 °C
Identity (IR): passes test

pictograms

Corrosion

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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