1188800

Diklofenak sodowy

United States Pharmacopeia (USP) Reference Standard

• Synonim(y): Diclofenac sodium salt, 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
• Wzór empiryczny (zapis Hilla): C₁₄H₁₀Cl₂NNaO₂
• Numer CAS: 15307-79-6
• Masa cząsteczkowa: 318.13
• Numer MDL: MFCD00082251
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329749565
• NACRES: NA.24

Właściwości

• klasa czystości: pharmaceutical primary standard
• rodzina API: diclofenac
• producent / nazwa handlowa: USP
• Zastosowanie: pharmaceutical (small molecule)
• Format: neat
• ciąg SMILES: [Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
• InChI: 1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
• Klucz InChI: KPHWPUGNDIVLNH-UHFFFAOYSA-M
• informacje o genach: human ... PTGS1(5742) , PTGS2(5743)

Opis

Opis ogólny

Diclofenac sodium is a sodium salt of diclofenac, a non-steroidal anti-inflammatory drug (NSAID). It prevents the synthesis of prostaglandin involved in pain, inflammation, and fever by inhibiting the cyclooxygenase enzyme activity.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

Diclofenac sodium USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare acid stage standard, standard, standard stock, sensitivity, and system suitability solution for the assay, impurity analysis, identification, and performance test by using liquid chromatography coupled with UV detector according to the given below monographs of United States Pharmacopeia (USP): 

• Diclofenac Sodium
• Diclofenac Sodium Delayed-Release Tablets  
• Diclofenac Sodium Extended-Release Tablets
• Diclofenac Sodium Topical Solution
• Diclofenac Sodium and Misoprostol Delayed-Release Tablets

Działania biochem./fizjol.

Standard NSAID and cyclooxygenase (COX) inhibitor. Major metabolites are 4´-hydroxydiclofenac and 5´-hydroxydiclofenac. Has been used as substrate selective for CYP2C9.

Komentarz do analizy

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Inne uwagi

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08,GHS09
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H301,H361d,H372,H411
• Zwroty wskazujące środki ostrożności: P202 - P260 - P264 - P270 - P273 - P301 + P310
• Klasyfikacja zagrożeń: Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable