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D6899
Diclofenac sodium salt
Synonim(y):
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
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About This Item
Wzór empiryczny (zapis Hilla):
C14H10Cl2NNaO2
Numer CAS:
Masa cząsteczkowa:
318.13
Numer WE:
Numer MDL:
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
NACRES:
NA.77
Polecane produkty
pochodzenie biologiczne
synthetic
Próba
≥98% (TLC)
Formularz
powder
mp
283-285 °C
rozpuszczalność
methanol: 50 mg/mL, clear, colorless to faint yellow or tan
inicjator
Novartis
temp. przechowywania
room temp
ciąg SMILES
[Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
InChI
1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
Klucz InChI
KPHWPUGNDIVLNH-UHFFFAOYSA-M
informacje o genach
human ... PTGS1(5742) , PTGS2(5743)
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Zastosowanie
Diclofenac sodium has been used:
- to investigate its radioprotective potential in a study
- to determine the basic viscosity and hydrodynamic values of the solubilizers and their micellar adducts in a study
- as a standard for potentiometric and fluorimetric determination of diclofenac in a sequential injection analysis system
- to inhibit phase II drug metabolizing enzyme (DME) in a study to investigate the inhibitory effects of an ethanol extract of Descurainia sophia seeds on Phase I and II DMEs
Działania biochem./fizjol.
Diclofenac sodium salt is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a competitive and irreversible inhibitor of prostaglandin synthetase. Its analgesic and anti-inflammatory activities are based on the prevention of the synthesis of arachinodate metabolites via cyclooxygenase inhibition. It is found to hinder the conversion of arachidonic acid to prostaglandins, which mediate inflammatory process. The NSAIDs are found to inhibit both cyclooxygenase enzymes, COX-1 and COX-2, causing undesirable gastrointestinal effect. Diclofenac sodium also functions as a scavenger of free radicals and serves a radioprotective role in restoring supercoiled form of plasmid DNA damaged by radiation back to normal. Diclofenac sodium is oxidized by the donation of electron and transfer of hydrogen atom. It can be a potential radioprotective agent.
Standard NSAID and cyclooxygenase (COX) inhibitor. Major metabolites are 4´-hydroxydiclofenac and 5´-hydroxydiclofenac. Has been used as substrate selective for CYP2C9.
Cechy i korzyści
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1
Kod klasy składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Amit Alok et al.
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The potential of clinical drug diclofenac sodium which is routinely used in clinics as non-steroid anti-inflammatory drugs opens a new insight in development of radioprotector. The drug has shown its potential radioprotective efficacy in clonogenic cell survival in Chinese hamster
Simultaneous potentiometric and fluorimetric determination of diclofenac in a sequential injection analysis system
Analytica Chimica Acta, 470, 185-194 (2002)
Diclofenac sodium (GP 45840, Voltaren), a potent inhibitor of prostaglandin synthetase.
E C Ku et al.
Biochemical pharmacology, 24(5), 641-643 (1975-03-01)
Jin-Mu Yi et al.
BMC complementary and alternative medicine, 15, 441-441 (2015-12-20)
Descurainia sophia seeds have a variety of pharmacological functions and been widely used in traditional folk medicine. However, their effects on human drug metabolizing enzyme (DME) activities have not been elucidated. The present study investigated the inhibitory effects of an
Seung-Hwan Jung et al.
Redox biology, 37, 101751-101751 (2020-10-21)
Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with various side effects, including cardiovascular and hepatic disorders. Studies suggest that mitochondrial damage and oxidative stress are important mediators of toxicity, yet the underlying mechanisms are poorly understood. In this study
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